Gap-junction communication between subtypes of direction-selective ganglion cells in the developing retina

DeBoer, D. J. and Vaney, D. I. (2005) Gap-junction communication between subtypes of direction-selective ganglion cells in the developing retina. Journal of Comparative Neurology, 482 1: 85-93. doi:10.1002/cne.20351


Author DeBoer, D. J.
Vaney, D. I.
Title Gap-junction communication between subtypes of direction-selective ganglion cells in the developing retina
Journal name Journal of Comparative Neurology   Check publisher's open access policy
ISSN 0021-9967
Publication date 2005
Sub-type Article (original research)
DOI 10.1002/cne.20351
Volume 482
Issue 1
Start page 85
End page 93
Total pages 9
Editor Clifford B. Saper
Place of publication New Jersey, USA
Publisher Wiley-Liss
Collection year 2005
Language eng
Subject C1
320705 Sensory Systems
780105 Biological sciences
Abstract The On-Off direction-selective ganglion cells (DSGCs) in the rabbit retina comprise four distinct subtypes that respond preferentially to image motion in four orthogonal directions; each subtype forms a regular territorial array, which is overlapped by the other three arrays. In this study, ganglion cells in the developing retina were injected with Neurobiotin, a gap-junction-permeable tracer, and the DSGCs were identified by their characteristic type 1 bistratified (BiS1) morphology. The complex patterns of tracer coupling shown by the BiSl ganglion cells changed systematically during the course of postnatal development. BiSl cells appear to be coupled together around the time of birth, but, over the next 10 days, BiSl cells decouple from each other, leading to the mature pattern in which only one subtype is coupled. At about postnatal day 5, before the ganglion cells become visually responsive, each of the BiSl cells commonly showed tracer coupling both to a regular array of neighboring BiSl cells, presumably destined to be DSGCs of the same subtype, and to a regular array of overlapping BiSl cells, presumably destined to be DSGCs of a different subtype. The gap-junction intercellular communication between subtypes of DSGCs with different preferred directions may play an important role in the differentiation of their synaptic connectivity, with respect to either the inputs that DSGCs receive from retinal interneurons or the outputs that DSGCs make to geniculate neurons. (C) 2004 Wiley-Liss, Inc.
Keyword Neurosciences
Zoology
Rabbit Retina
Tracer Coupling
Synchrony
Starburst Amacrine Cells
Developing Mammalian Retina
Receptive-fields
Dendritic Architecture
Cholinergic Neurons
Image Motion
Chick Retina
Cat Retina
Mechanisms
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 04:14:03 EST