Psilocybin impairs high-level but not low-level motion perception

Carter, OL, Pettigrew, JD, Burr, DC, Alais, D, Hasler, F and Vollenweider, FX (2004) Psilocybin impairs high-level but not low-level motion perception. Neuroreport, 15 12: 1947-1951. doi:10.1097/00001756-200408260-00023


Author Carter, OL
Pettigrew, JD
Burr, DC
Alais, D
Hasler, F
Vollenweider, FX
Title Psilocybin impairs high-level but not low-level motion perception
Journal name Neuroreport   Check publisher's open access policy
ISSN 0959-4965
Publication date 2004
Sub-type Article (original research)
DOI 10.1097/00001756-200408260-00023
Volume 15
Issue 12
Start page 1947
End page 1951
Total pages 5
Editor Georgio Gabella
Place of publication London
Publisher Lippincott, Williams and Wilkins
Collection year 2004
Language eng
Subject C1
730211 Mental health
321016 Opthalmology and Vision Science
730111 Hearing, vision, speech and their disorders
Abstract The hallucinogenic serotonin(IA&2A) agonist psilocybin is known for its ability to induce illusions of motion in otherwise stationary objects or textured surfaces. This study investigated the effect of psilocybin on local and global motion processing in nine human volunteers. Using a forced choice direction of motion discrimination task we show that psilocybin selectively impairs coherence sensitivity for random dot patterns, likely mediated by high-level global motion detectors, but not contrast sensitivity for drifting gratings, believed to be mediated by low-level detectors. These results are in line with those observed within schizophrenic populations and are discussed in respect to the proposition that psilocybin may provide a model to investigate clinical psychosis and the pharmacological underpinnings of visual perception in normal populations.
Keyword Neurosciences
Hallucinogen
Human
Motion
Perception
Psilocybin
Schizophrenia
Vision
Response Properties
Visual-cortex
Area Mt
Contrast
5-hydroxytryptamine
Psychophysics
Consciousness
Integration
Receptor
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 04:13:11 EST