Moving molecules: mRNA trafficking in mammalian oligodendrocytes and neurons

Smith, Ross (2004) Moving molecules: mRNA trafficking in mammalian oligodendrocytes and neurons. Neuroscientist, 10 6: 495-500. doi:10.1177/1073858404266759

Author Smith, Ross
Title Moving molecules: mRNA trafficking in mammalian oligodendrocytes and neurons
Journal name Neuroscientist   Check publisher's open access policy
ISSN 1073-8584
Publication date 2004
Sub-type Article (original research)
DOI 10.1177/1073858404266759
Volume 10
Issue 6
Start page 495
End page 500
Total pages 6
Place of publication USA
Publisher Sage
Collection year 2004
Language eng
Subject C1
270199 Biochemistry and Cell Biology not elsewhere classified
780105 Biological sciences
Abstract Numerous mRNA molecules are localized in regions of the dendrites of neurons, some moving along dendrites in response to synaptic activity. The proteins encoded by these RNAs have diverse functions, including participation in memory formation and long-term potentiation. Recent experiments have shown that a cytoplasmic RNA trafficking pathway described for oligodendrocytes also operates in neurons. Transported RNAs possess a cis-acting element that directs them to granules, which are transported along microtubules by the motor proteins kinesin and dynein. These RNA molecules are recruited to the cytoplasmic transport granules by cooperative interaction with a cognate trans-acting factor. mRNAs containing the 11-nucleotide A2RE11 or 21-nucleotide A2RE sequences bind heterogeneous nuclear ribonucleoproteins A2 and A3, which are abundant in the brain. Mutations in this cis-acting element that weaken its interaction with hnRNP A2 also interfere with RNA trafficking. Several dendritically localized mRNAs, including those encoding calcium-calmodulin-dependent protein kinase 11 a subunit and neurogranin, possess A2RE-like sequences, suggesting that they may be localized by interaction with these heterogeneous nuclear ribonucleoproteins. Calcium-calmodulin-dependent protein kinase 11 a subunit is of particular interest: Its RNA is transported in depolarized neurons, and the protein it encodes is essential for establishing long-term memory. Several other cis-acting sequences and trans-acting factors that participate in neuronal RNA localization have been discovered.
Keyword Neurosciences
Rna Localization
Cis-acting Sequences
Trans-acting Factors
Dendritic Targeting Element
Mental-retardation Protein
Memory Consolidation
Synaptic Plasticity
Bc1 Rna
Clinical Neurology
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 04:12:44 EST