Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P-falciparum malaria

Walsh, DS, Eamsila, C, Sasiprapha, T, Sangkharomya, S, Khaewsathien, P, Supakalin, P, Tang, DB, Jarasrumgsichol, P, Cherdchu, C, Edstein, MD, Rieckmann, KH and Brewer, TG (2004) Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P-falciparum malaria. Journal of Infectious Diseases, 190 8: 1456-1463. doi:10.1086/424468


Author Walsh, DS
Eamsila, C
Sasiprapha, T
Sangkharomya, S
Khaewsathien, P
Supakalin, P
Tang, DB
Jarasrumgsichol, P
Cherdchu, C
Edstein, MD
Rieckmann, KH
Brewer, TG
Title Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P-falciparum malaria
Journal name Journal of Infectious Diseases   Check publisher's open access policy
ISSN 0022-1899
Publication date 2004
Sub-type Article (original research)
DOI 10.1086/424468
Volume 190
Issue 8
Start page 1456
End page 1463
Total pages 8
Editor M.S. Hirsch
Place of publication United States
Publisher University of Chicago Press
Collection year 2004
Language eng
Subject C1
321010 Infectious Diseases
730212 Disease distribution and transmission
Abstract We assessed monthly doses of tafenoquine for preventing Plasmodium vivax and multidrug-resistant P. falciparum malaria. In a randomized, double-blind, placebo-controlled study, 205 Thai soldiers received either a loading dose of tafenoquine 400 mg ( base) daily for 3 days, followed by single monthly 400-mg doses (n = 104), or placebo (n = 101), for up to 5 consecutive months. In volunteers completing follow-up (96 tafenoquine and 91 placebo recipients), there were 22 P. vivax, 8 P. falciparum, and 1 mixed infection. All infections except 1 P. vivax occurred in placebo recipients, giving tafenoquine a protective efficacy of 97% for all malaria (95% confidence interval [CI], 82%-99%), 96% for P. vivax malaria (95% CI, 76%-99%), and 100% for P. falciparum malaria ( 95% CI, 60%-100%). Monthly tafenoquine was safe, well tolerated, and highly effective in preventing P. vivax and multidrug-resistant P. falciparum malaria in Thai soldiers during 6 months of prophylaxis.
Keyword Infectious Diseases
Wr 238605
Antimalarial Agent
8-aminoquinoline Antimalarial
Wr-238605
Pharmacokinetics
Primaquine
Chemoprophylaxis
Chloroquine
Mefloquine
Thailand
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 04:05:10 EST