Mapping hippocampal and ventricular change in Alzheimer disease

Thompson, P. M., Hayashi, K. M., de Zubicaray, G. I., Janke, A. L., Rose, S. E., Semple, J., Hong, M. S., Herman, D. H., Gravano, D., Doddrell, D. M. and Toga, A. W. (2004) Mapping hippocampal and ventricular change in Alzheimer disease. Neuroimage, 22 4: 1754-1766. doi:10.1016/j.neuroimage.2004.03.040

Author Thompson, P. M.
Hayashi, K. M.
de Zubicaray, G. I.
Janke, A. L.
Rose, S. E.
Semple, J.
Hong, M. S.
Herman, D. H.
Gravano, D.
Doddrell, D. M.
Toga, A. W.
Title Mapping hippocampal and ventricular change in Alzheimer disease
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2004
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2004.03.040
Volume 22
Issue 4
Start page 1754
End page 1766
Total pages 13
Editor A.W. Toga
J.C. Mazziotta
R.S.J. Frackowiak
Place of publication San Diego
Publisher Academic Press
Collection year 2004
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract We developed an anatomical mapping technique to detect hippocampal and ventricular changes in Alzheimer disease (AD). The resulting maps are sensitive to longitudinal changes in brain structure as the disease progresses. An anatomical surface modeling approach was combined with surface-based statistics to visualize the region and rate of atrophy in serial MRI scans and isolate where these changes link with cognitive decline. Fifty-two high-resolution MRI scans were acquired from 12 AD patients (age: 68.4 +/- 1.9 years) and 14 matched controls (age: 71.4 +/- 0.9 years), each scanned twice (2.1 +/- 0.4 years apart). 3D parametric mesh models of the hippocampus and temporal horns were created in sequential scans and averaged across subjects to identify systematic patterns of atrophy. As an index of radial atrophy, 3D distance fields were generated relating each anatomical surface point to a medial curve threading down the medial axis of each structure. Hippocampal atrophic rates and ventricular expansion were assessed statistically using surface-based permutation testing and were faster in AD than in controls. Using color-coded maps and video sequences, these changes were visualized as they progressed anatomically over time. Additional maps localized regions where atrophic changes linked with cognitive decline. Temporal horn expansion maps were more sensitive to AD progression than maps of hippocampal atrophy, but both maps correlated with clinical deterioration. These quantitative, dynamic visualizations of hippocampal atrophy and ventricular expansion rates in aging and AD may provide a promising measure to track AD progression in drug trials. (C) 2004 Elsevier Inc. All rights reserved.
Keyword Neurosciences
Radiology, Nuclear Medicine & Medical Imaging
Alzheimer Disease
Longitudinal Imaging
Brain Mapping
Mild Cognitive Impairment
Medial Temporal-lobe
Gray-matter Loss
Entorhinal Cortex
Serial Mri
Genetic Contributions
Brain Structure
Q-Index Code C1

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