Distal limb cryotherapy for the prevention of acute laminitis

Van Eps, Andrew W., Walters, Lester J., Baldwin, Gregory I., McGarry, Mark and Pollitt, Christopher C. (2004) Distal limb cryotherapy for the prevention of acute laminitis. Clinical Techniques in Equine Practice, 3 1: 64-70. doi:10.1053/j.ctep.2004.07.006


Author Van Eps, Andrew W.
Walters, Lester J.
Baldwin, Gregory I.
McGarry, Mark
Pollitt, Christopher C.
Title Distal limb cryotherapy for the prevention of acute laminitis
Journal name Clinical Techniques in Equine Practice   Check publisher's open access policy
ISSN 1534-7516
Publication date 2004-03-01
Year available 2004
Sub-type Article (original research)
DOI 10.1053/j.ctep.2004.07.006
Volume 3
Issue 1
Start page 64
End page 70
Total pages 7
Place of publication Philadelphia, Pa., U.S.A.
Publisher W.B. Saunders & Co.
Collection year 2004
Language eng
Subject C1
300501 Veterinary Medicine
630107 Minor livestock (e.g. horses, goats, deer)
07 Agricultural and Veterinary Sciences
0707 Veterinary Sciences
Formatted abstract
Acute laminitis can be a devastating consequence of systemic diseases such as severe colitis, proximal enteritis and metritis. Prophylactic therapies based on enhancing digital perfusion during the developmental phase of laminitis have resulted in only limited efficacy. Recent insights into the pathophysiology of acute laminitis have lead to the evaluation of cryotherapy for prevention of the disease. Experimental evidence demonstrates that the equine digit is particularly resilient with respect to the potentially detrimental effects of prolonged, extreme cold. Continuous distal limb cryotherapy during the developmental phase was effective in markedly reducing the severity of laminitis in an experimental model, and limited preliminary data suggests a similar effect in clinical cases of colitis. The mechanisms by which cryotherapy may prevent laminitis are unclear. Potent vasoconstriction of the digital circulation could prevent the delivery of systemic “trigger factors” to the digit. A cold-induced potent hypometabolic state within the laminar tissue may protect the laminae from damage regardless of the pathophysiological insult. The authors advocate the continuous application of cryotherapy to the distal limbs of clinical cases that are at high risk of developing acute laminitis. There is currently no evidence to support the use of cryotherapy in horses with preexisting acute laminitis.
Keyword Laminitis prevention
Pathophysiology
Continuous distal limb cryotherapy
Developmental phase
Colitis
Vasoconstriction
Hypometabolism
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 13:58:18 EST