Treatment of eight dogs with nasal tumours with a alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam

Langova, V., Mutsaers, A. J., Phillips, B. and Straw, R. (2004-11) Treatment of eight dogs with nasal tumours with a alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam. Australian Veterinary Journal, 82 11: 676-680.

Document type:	Journal Article
Collections:	Excellence in Research Australia (ERA) - Collection School of Veterinary Science Publications

Author(s)	Langova, V. Mutsaers, A. J. Phillips, B. Straw, R.
Title	Treatment of eight dogs with nasal tumours with a alternating doses of doxorubicin and carboplatin in conjunction with oral piroxicam
Journal name	Australian Veterinary Journal
Publication date	2004-11
Sub-type	Article
Volume number	82
Issue number	11
ISSN	0005-0423
Start page	676
End page	680
Total pages	5
Editor(s)	Maureen Revington
Place of publication	Australia
Publisher	Australian Vet. Assoc.
Collection year	2004
Language	eng
Subject	C1 300501 Veterinary Medicine 780105 Biological sciences
Abstract	Objective To determine the efficacy and toxicity of chemotherapy in the treatment of canine nasal tumours. Design Retrospective clinical study Procedure Eight dogs with histologically confirmed nasal tumours were staged by means of complete blood count, serum biochemical analysis, cytological analysis of fine needle aspirate of the regional lymph nodes, thoracic radiographs and computed tomography scan of the nasal cavity. All dogs were treated with alternating doses of doxorubicin, carboplatin and oral piroxicam. All dogs were monitored for side effects of chemotherapy and evaluated for response to treatment by computed tomography scan of the nasal cavity after the first four treatments. Results Complete remission was achieved in four dogs, partial remission occurred in two dogs and two had stable disease on the basis of computed tomography evaluation. There was resolution of clinical signs after one to two doses of chemotherapy in all dogs. Conclusions This chemotherapy protocol was efficacious and well tolerated in this series of eight cases of canine nasal tumours.
Keyword(s)	Tumours Doxorubicin Oral Piroxicam Veterinary Sciences Canine Nasal Megavoltage Irradiation Radiotherapy Survival Chemotherapy Neoplasms Therapy Adenocarcinoma Diagnosis Radiation