Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis

Warren, Matthew J., Roddam, Louise F., Power, Peter M., Terry, Tamsin D. and Jennings, Michael P. (2004) Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis. Fems Immunology And Medical Microbiology, 41 1: 43-50.


Author Warren, Matthew J.
Roddam, Louise F.
Power, Peter M.
Terry, Tamsin D.
Jennings, Michael P.
Title Analysis of the role of pglI in pilin glycosylation of Neisseria meningitidis
Journal name Fems Immunology And Medical Microbiology   Check publisher's open access policy
ISSN 0928-8244
Publication date 2004-05
Sub-type Article (original research)
DOI 10.1016/j.femsim.2004.01.002
Volume 41
Issue 1
Start page 43
End page 50
Total pages 8
Place of publication Amsterdam
Publisher Elsevier Science Bv
Collection year 2004
Language eng
Subject C1
270300 Microbiology
780105 Biological sciences
Abstract Pilin is the major subunit of the essential virulence factor pili and is glycosylated at Ser63. In this study we investigated the gene pglI to determine whether it is involved in the biosynthesis of the pilin-linked glycan of Neisseria meningitidis strain C311#3. A N. meningitidis C311#3pglI mutant resulted in a change of apparent molecular weight in SDS-PAGE and altered binding of antisera, consistent with a role in the biosynthesis of the pilin-linked glycan. These data, in conjunction with homology with well-characterised acyltransferases suggests a specific role for pglI in the biosynthesis of the basal 2,4-diacetamido-2,4,6-trideoxyhexose residue of the pilin-linked glycan. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Microbiological Societies.
Keyword Immunology
Infectious Diseases
Microbiology
Complete Genome Sequence
Typhimurium O-antigen
Phase-variable Genes
Molecular Characterization
Pathogenic Neisseria
Meningococcal Pilin
Endothelial-cells
Serogroup-b
Strain Mc58
Protein
Q-Index Code C1

 
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