Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians

Foley, P. F., Loh, E. W., Innes, D. J., Williams, S. M., Tannenberg, A. E. G., Harper, C. G. and Dodd, P. R. (2004) Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians. Annals of the New York Academy of Science, 1025 39-46. doi:10.1196/annals.1316.005

Author Foley, P. F.
Loh, E. W.
Innes, D. J.
Williams, S. M.
Tannenberg, A. E. G.
Harper, C. G.
Dodd, P. R.
Title Association studies of neurotransmitter gene polymorphisms in alcoholic Caucasians
Journal name Annals of the New York Academy of Science   Check publisher's open access policy
ISSN 0077-8923
ISBN 1-57331-522-2
Publication date 2004-10
Sub-type Article (original research)
DOI 10.1196/annals.1316.005
Volume 1025
Start page 39
End page 46
Total pages 8
Editor Douglas Braaten
Place of publication New York, U.S.A.
Publisher Wiley-Blackwell
Collection year 2004
Language eng
Subject C1
320702 Central Nervous System
270203 Population and Ecological Genetics
270210 Neurogenetics
730205 Substance abuse
730104 Nervous system and disorders
Formatted abstract
Ethanol enhances mesolimbic/cortical dopamine activity in reward and reinforcement circuits. We investigated the hypothesis that risk for alcoholism may be mediated by genes for neurotransmitters associated with the dopamine reward system as well as genes for enzymes involved in ethanol metabolism. DNA was extracted from brain tissue collected at autopsy from pathologically characterized alcoholics and controls. PCR-based assays showed that alcoholism was associated with polymorphisms of the dopamine D2 receptor (DRD2) TaqI B (P = .029) and the GABAA-β2 subunit C1412T (P = .012) genes, but not with the glutamate receptor subunit gene NMDAR2B (366C/G), the serotonin transporter gene (5HTTL-PR), the dopamine transporter gene DAT1(SLC6A3), the dopamine D2 receptor gene DRD2 TaqI A, or the GABAA α1(A15G), α6(T1519C), and γ2(G3145A) subunit genes. The glial glutamate transporter gene EAAT2 polymorphism G603A was associated with alcoholic cirrhosis (P = .048). The genotype for the most active alcohol dehydrogenase enzyme ADH1C was associated with a lower risk of alcoholism (P = .026) and was less prevalent in alcoholics with DRD2TaqIA2/A2 (P = .047), GABAA-β2 1412C/C (P = .01), or EAAT2 603G/A (P = .022) genotypes. Combined DRD2TaqI A or B with GABAA-β2 or EAAT2 G603A genotypes may have a concerted influence in the predisposition to alcoholism.
© 2004 New York Academy of Sciences.
Keyword Multidisciplinary Sciences
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 03:44:21 EST