Acetazolamide reduces exercise capacity and increases leg fatigue under hypoxic conditions

Garske, Luke A., Brown, Michael G. and Morrison, Stephen C. (2003) Acetazolamide reduces exercise capacity and increases leg fatigue under hypoxic conditions. Journal of Applied Physiology, 94 3: 991-996. doi:10.1152/japplphysiol.00746.2001

Author Garske, Luke A.
Brown, Michael G.
Morrison, Stephen C.
Title Acetazolamide reduces exercise capacity and increases leg fatigue under hypoxic conditions
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
Publication date 2003-03
Sub-type Article (original research)
DOI 10.1152/japplphysiol.00746.2001
Volume 94
Issue 3
Start page 991
End page 996
Total pages 6
Editor G. C. Sieck
Place of publication Bethesda, U.S.A.
Publisher American Physiological Society
Collection year 2004
Language eng
Subject C1
321027 Respiratory Diseases
730110 Respiratory system and diseases (incl. asthma)
Abstract Acetazolamide (Acz) is used at altitude to prevent acute mountain sickness, but its effect on exercise capacity under hypoxic conditions is uncertain. Nine healthy men completed this double-blind, randomized, crossover study. All subjects underwent incremental exercise to exhaustion with an inspired O-2 fraction of 0.13, hypoxic ventilatory responses, and hypercapnic ventilatory responses after Acz (500 mg twice daily for 5 doses) and placebo. Maximum power of 203 +/- 38 (SD) Won Acz was less than the placebo value of 225 +/- 40 W (P < 0.01). At peak exercise, arterialized capillary pH was lower and PO2 higher on Acz (P < 0.01). Ventilation was 118.6 +/- 20.0 l/min at the maximal power on Acz and 102.4 +/- 20.7 l/min at the same power on placebo (P < 0.02), and Borg score for leg fatigue was increased on Acz (P < 0.02), with no difference in Borg score for dyspnea. Hypercapnic ventilatory response on Acz was greater (P < 0.02), whereas hypoxic ventilatory response was unchanged. During hypoxic exercise, Acz reduced exercise capacity associated with increased perception of leg fatigue. Despite increased ventilation, dyspnea was not increased.
Keyword Physiology
Sport Sciences
Control Of Breathing
Respiratory Muscle Work
Carbonic-anhydrase Inhibition
Low-dose Acetazolamide
Maximal Exercise
Ventilatory Responses
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
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Created: Wed, 15 Aug 2007, 03:40:45 EST