Prostaglandin E2 enhances alveolar bone formation in the rat mandible

Ramirez-Yanez, G. O., Seymour, G. J., Walsh, L. J., Forwood, M. R. and Symons, A. L. (2004) Prostaglandin E2 enhances alveolar bone formation in the rat mandible. Bone, 35 6: 1361-1368. doi:10.1016/j.bone.2004.08.006

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Author Ramirez-Yanez, G. O.
Seymour, G. J.
Walsh, L. J.
Forwood, M. R.
Symons, A. L.
Title Prostaglandin E2 enhances alveolar bone formation in the rat mandible
Formatted title
Prostaglandin E2 enhances alveolar bone formation in the rat mandible
Journal name Bone   Check publisher's open access policy
ISSN 8756-3282
Publication date 2004-12
Sub-type Article (original research)
DOI 10.1016/j.bone.2004.08.006
Open Access Status File (Author Post-print)
Volume 35
Issue 6
Start page 1361
End page 1368
Total pages 8
Place of publication New York, U.S.A.
Publisher Elsevier
Collection year 2004
Language eng
Subject C1
730112 Oro-dental and disorders
730114 Skeletal system and disorders (incl. arthritis)
110599 Dentistry not elsewhere classified
110314 Orthopaedics
1105 Dentistry
Formatted abstract
Prostaglandin E2 (PGE2) induces bone formation in stress-bearing bones. The mandible, a stress-bearing bone, is loaded daily during mastication. The aim of this study was to determine if PGE2 delivered locally to the mandible over 20 days enhances alveolar bone deposition. In 18 Lewis rats, controlled-release pellets containing PGE2 were implanted on the buccal aspect on the left-hand side of the mandible, mesial to the root of the first molar. Controlled-release pellets locally delivered 0.1, 0.05, or 0.025 mg/day of PGE2. The right side of the mandible was used as a matched control for each animal. Six sham-treated animals were implanted with a placebo pellet. On days 7 and 19, animals were injected with the bone markers tetracycline and calcein, respectively. On day 21, animals were sacrificed and undecalcified tissues obtained for morphometrical analysis. Morphometrical measurements were analyzed by paired t test to determine differences between the matched samples and one-way ANOVA to compare the different treatment groups. 
A significant increase in alveolar bone area was observed in mandibles treated with 0.1 and 0.05 mg/day when compared with matched controls and the placebo group. This was accompanied by a significant increase in alveolar bone height and width. The proportions of double-labeled surface (dLS), the mineral apposition rate (MAR), and bone formation rate (BFR) were significantly increased in mandibles treated with the two higher doses of PGE2. The proportion of resorptive surface (RS) was significantly reduced in these two groups.  It is concluded that PGE2 induces alveolar bone formation in the mandible when locally delivered at a dose of 0.1 or 0.05 mg/day for 20 days.
Keyword Aged rats
Alveolar bone
Bone histomorphometry
Bone markers
Bone modeling
Cancellous bone
Cortical bone
Controlled-release pellets
Endocrinology &metabolism
Female rats
Prostaglandin E
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Dentistry Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 03:40:43 EST