Hepatitis B virus genotypes, core gene variability and ethnicity in the Pacific region

Jazayeri, Mohammed S., Basuni, Ashraf A., Cooksley, Graham, Locarnini, Stephen and Carman, William F. (2004) Hepatitis B virus genotypes, core gene variability and ethnicity in the Pacific region. Journal of Hepatology, 41 1: 139-146. doi:10.1016/j.jhep.2004.03.025


Author Jazayeri, Mohammed S.
Basuni, Ashraf A.
Cooksley, Graham
Locarnini, Stephen
Carman, William F.
Title Hepatitis B virus genotypes, core gene variability and ethnicity in the Pacific region
Journal name Journal of Hepatology   Check publisher's open access policy
ISSN 0168-8278
Publication date 2004-07
Sub-type Article (original research)
DOI 10.1016/j.jhep.2004.03.025
Volume 41
Issue 1
Start page 139
End page 146
Total pages 8
Editor J. Rodes
Place of publication Copenhagen, Denmark
Publisher Elsevier BV
Collection year 2004
Language eng
Subject C1
321010 Infectious Diseases
730101 Infectious diseases
Formatted abstract
Background/Aims:
The world-wide distribution of hepatitis B virus (HBV) genotypes follows a geographic pattern under the influence of ethnic background.

Methods:
Forty eight core genes from four pacific islands were compared with the following findings.

Results:

First, island-specific variant substitutions were found for only two out of four islands.
Second, 11 amino acid and 90 nucleotide changes specific for pacific genotypes C and D were defined.
Third, the nucleotide diversity of genotype C (all but one were silent) was greater than that of genotype D.

Conclusions:
These results suggest an early appearance of genotype C in the pacific with few subsequent amino acid changes because of shared immunological responses across the region followed by random silent changes, some of which reflect isolation of individual island populations. Genotype D appeared later. (C) 2004 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Keyword Gastroenterology & Hepatology
Hbcag Variability
Hbv Adrq- Subtype
Pacific-specific Core Gene Sequences
Surface-antigen Subtypes
Hla Class-i
Phylogenetic Relatedness
Mitochondrial Dnas
Central-america
Strains
Association
Sequences
Infection
Allele
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 03:40:32 EST