Virus-specific CD8+ T lymphocytes within the normal human liver

Ward, S. M., Jonsson, J. R., Sierro, S., Clouston, A. D., Lucas, M., Vargas, A. L., Powell, E. E. and Klenerman, P. (2004) Virus-specific CD8+ T lymphocytes within the normal human liver. European Journal of Immunology, 34 6: 1526-1531. doi:10.1002/eji.200324275

Author Ward, S. M.
Jonsson, J. R.
Sierro, S.
Clouston, A. D.
Lucas, M.
Vargas, A. L.
Powell, E. E.
Klenerman, P.
Title Virus-specific CD8+ T lymphocytes within the normal human liver
Journal name European Journal of Immunology   Check publisher's open access policy
ISSN 0014-2980
Publication date 2004
Sub-type Article (original research)
DOI 10.1002/eji.200324275
Volume 34
Issue 6
Start page 1526
End page 1531
Total pages 6
Editor L. Leclercq Reth
Place of publication Germany
Publisher Wiley - VCH Verlag GmbH & Co. KGaA
Collection year 2004
Language eng
Subject C1
321006 Gastroenterology and Hepatology
730118 Organs, diseases and abnormal conditions not elsewhere classified
Abstract The frequency and phenotype of human antiviral memory CD8(+) T cells in blood are well studied, yet little is known about their distribution within tissues. Analysis of antiviral CD8(+) T cell populations derived from a unique set of normal liver and blood samples identified a consistent population of virus-specific cells within the liver. In comparison to the circulating T cells, the liver-derived T cells were present at frequencies which were variably enriched compared to that in the blood, and showed significant differences with regard to the expression of CD45RA, CD45RO, CD95, CCR7, CD27 and CD28. The differences in these cell surface markers are consistent with a mature 'effector memory' phenotype of antigen-specific CD8(+) T cells within the liver. An enrichment of an activated subset of NKT cells (Valpha24/Vbeta11) was also observed, a finding which may be relevant to the regulation of the antiviral population:.
Keyword Immunology
Human Liver
Hepatitis-c Virus
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 24 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 03:33:46 EST