Gender diagnosticity and androgen receptor gene CAG repeat sequence

Loehlin, John C., Jonsson, Erik G., Gustavsson, J. Petter, Schalling, Martin, Medland, Sarah E., Montgomery, Grant W. and Martin, Nicholas G. (2004) Gender diagnosticity and androgen receptor gene CAG repeat sequence. Twin Research, 7 5: 456-461. doi:10.1375/1369052042335359

Author Loehlin, John C.
Jonsson, Erik G.
Gustavsson, J. Petter
Schalling, Martin
Medland, Sarah E.
Montgomery, Grant W.
Martin, Nicholas G.
Title Gender diagnosticity and androgen receptor gene CAG repeat sequence
Journal name Twin Research   Check publisher's open access policy
ISSN 1369-0523
Publication date 2004
Sub-type Article (original research)
DOI 10.1375/1369052042335359
Volume 7
Issue 5
Start page 456
End page 461
Total pages 6
Editor N.G. Martin
K.M. Kirk
Place of publication Bowen Hills, QLD, Australia
Publisher Australian Academic Press
Collection year 2004
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract The gender diagnosticity (GD) approach of Lippa (1995) was used to evaluate the relationship of within-sex differences in psychological masculinity-femininity to a genetic characteristic, the length of a repeated CAG sequence in the X-linked androgen receptor (AR) gene. Previously assessed adult samples in Australia and Sweden were used for this purpose. A weak relationship (correlations in the range .11 to .14) was obtained in both countries. Additional data from adolescent twins from Australia (12-, 14-, 16-year-olds) did not confirm such a relationship at those ages, especially for males. The fact that this sample consisted of twins permitted two kinds of within-pair comparisons: (1) Did the dizygotic twin who had the longer AR sequence have the higher GD score? (2) Was one twin's GD score more highly correlated with the other twin's AR score in MZ than in DZ pairs? The answer in both cases was negative. Clarification of these relationships will require large samples and measurements at additional ages.
Keyword Genetics and heredity
Obstetrics and gynecology
Reproductive biology
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 03:24:41 EST