Role of tumor suppressors in DNA damage response

Zhou, Bin-Bing S., Mattern, Michael R. and Khanna, Kum Kum (2003) Role of tumor suppressors in DNA damage response. Methods in Molecular Biology, 223 39-50. doi:10.1385/1592593291

Author Zhou, Bin-Bing S.
Mattern, Michael R.
Khanna, Kum Kum
Title Role of tumor suppressors in DNA damage response
Journal name Methods in Molecular Biology   Check publisher's open access policy
ISSN 1064-3745
ISBN 9780896039872
Publication date 2003
Sub-type Article (original research)
DOI 10.1385/1592593291
Volume 223
Start page 39
End page 50
Total pages 12
Editor W. S. El-Deiry
Place of publication Totowa, U.S.
Publisher Humana Press
Language eng
Subject 321015 Oncology and Carcinogenesis
730108 Cancer and related disorders
1112 Oncology and Carcinogenesis
Formatted abstract
Studies of human cancer predisposition syndromes and mouse knockout models have revealed several connections between defects in DNA damage response and tumorigenesis. Several recently identified genes, including ATM (ataxia telangiectasia mutated), BRCA1, BRCA2, and Nbs1 (Nijmegen breakage syndrome gene), act as tumor suppressors by regulating various aspects of the cellular damage response pathway. In all of these cases, inactivating mutations cause defects in DNA damage signaling, giving rise to some form of chromosomal instability and predisposition to cancer. This chapter is concerned with the relationship between these tumor suppressors and the cellular DNA damage response, and focuses primarily on how defects in the tumor suppressor-dependent DNA damage signaling pathway may cause genetic instability, thereby facilitating tumorigenesis, and, in s ome cases, providing an opportunity for selective therapy. © Humana Press Inc.
Keyword Tumor suppressors
Q-Index Code B1
Additional Notes Volume is titled "Tumor Suppressor Genes: Regulation, Function,and Medicinal Applications".

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
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Created: Tue, 14 Aug 2007, 11:23:31 EST