Piecing together evolution of the vertebrate endocrine system

Campbell, RK, Satoh, N and Degnan, BM (2004) Piecing together evolution of the vertebrate endocrine system. Trends In Genetics, 20 8: 359-366. doi:10.1016/j.tig.2004.06.005


Author Campbell, RK
Satoh, N
Degnan, BM
Title Piecing together evolution of the vertebrate endocrine system
Journal name Trends In Genetics   Check publisher's open access policy
ISSN 0168-9525
Publication date 2004
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tig.2004.06.005
Volume 20
Issue 8
Start page 359
End page 366
Total pages 8
Editor J. Alfred
M. Thorne
Place of publication UK
Publisher Elsevier Ltd
Collection year 2004
Language eng
Subject C1
770302 Living resources (incl. impacts of fishing on non-target species)
270208 Molecular Evolution
Abstract One of the great challenges in biology is to understand how particular complex morphological and physiological characters originated in specific evolutionary lineages. In this article, we address the origin of the vertebrate hypothalamic-pituitary-peripheral gland (H-P-PG) endocrine system, a complex network of specialized tissues, ligands and receptors. Analysis of metazoan nucleotide and protein sequences reveals a patchwork pattern of H-P-PG gene conservation between vertebrates and closely related invertebrates (ascidians). This is consistent with a model of how the vertebrate H-P-PG endocrine system could have emerged in relatively few steps by gene family expansion and by regulatory and structural modifications to genes that are present in a chordate ancestor. Some of these changes might have resulted in new connections between metabolic or signaling pathways, such as the bridging of 'synthesis islands' to form an efficient system for steroid hormone synthesis.
Keyword Genetics & Heredity
Human Chorionic-gonadotropin
Progesterone 21-hydroxylase Activity
Protein-coupled Receptors
Ascidian Ciona-savignyi
Luteinizing-hormone
Beta-subunits
Intestinalis
Genes
Sequence
Genome
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Biological Sciences Publications
 
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Created: Wed, 15 Aug 2007, 03:05:10 EST