T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis

Yamazaki, K., Ohsawa, Y., Itoh, H., Ueki, K., Tabeta, K., Oda, T., Nakajima, T., Yoshie, H., Saito, S., Oguma, F., Kodama, M., Aizawa, Y. and Seymour, G. J. (2004) T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis. Oral Microbiology and Immunology, 19 3: 160-167. doi:10.1111/j.0902-0055.2004.00134.x


Author Yamazaki, K.
Ohsawa, Y.
Itoh, H.
Ueki, K.
Tabeta, K.
Oda, T.
Nakajima, T.
Yoshie, H.
Saito, S.
Oguma, F.
Kodama, M.
Aizawa, Y.
Seymour, G. J.
Title T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis
Formatted title
T-cell clonality to Porphyromonas gingivalis and human heat shock protein 60s in patients with atherosclerosis and periodontitis
Journal name Oral Microbiology and Immunology   Check publisher's open access policy
ISSN 0902-0055
Publication date 2004
Sub-type Article (original research)
DOI 10.1111/j.0902-0055.2004.00134.x
Volume 19
Issue 3
Start page 160
End page 167
Total pages 8
Editor J. Slots
Place of publication Denmark
Publisher Blackwell Munksgaard
Collection year 2004
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
Abstract Individuals with periodontitis have been reported to have a significantly increased risk of developing coronary heart disease. Several studies have demonstrated that the immune response to heat shock protein 60 (HSP60) may be involved in the pathogenesis of both atherosclerosis and chronic periodontitis. To investigate this possible link between these diseases, cellular and humoral immune responses to HSP60 in atherosclerosis patients were compared with those in periodontitis patients and healthy subjects using human and Porphyromonas gingivalis HSP60 (GroEL) as antigens. Antibody levels to both human and P. gingivalis HSP60s were the highest in atherosclerosis patients, followed by periodontitis patients and healthy subjects. Clonal analysis of the T cells clearly demonstrated the presence of not only human HSP60- but also P. gingivalis GroEL-reactive T-cell populations in the peripheral circulation of atherosclerosis patients. Furthermore, these HSP60-reactive T cells seemed to be present in atherosclerotic lesions in some patients. These results suggest that T-cell clones with the same specificity may be involved in the pathogenesis of the different diseases.
Keyword Dentistry, Oral Surgery & Medicine
Immunology
Microbiology
Atherosclerosis
Hsp60
Periodontitis
Immunological Characterization
Endothelial Cytotoxicity
Chlamydia-pneumoniae
Immune-response
Follow-up
Protein
Receptor
Lesions
Macrophages
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2005 Higher Education Research Data Collection
School of Dentistry Publications
 
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Created: Wed, 15 Aug 2007, 02:58:27 EST