A national case-control study of Ewing's sarcoma family of tumours in Australia

Valery, P. C., McWhirter, W. R., Sleigh, A., Williams, G. and Bain, C. (2003) A national case-control study of Ewing's sarcoma family of tumours in Australia. International Journal of Cancer, 105 6: 825-830. doi:10.1002/ijc.11129


Author Valery, P. C.
McWhirter, W. R.
Sleigh, A.
Williams, G.
Bain, C.
Title A national case-control study of Ewing's sarcoma family of tumours in Australia
Journal name International Journal of Cancer   Check publisher's open access policy
ISSN 0020-7136
Publication date 2003
Sub-type Article (original research)
DOI 10.1002/ijc.11129
Volume 105
Issue 6
Start page 825
End page 830
Total pages 6
Editor H. Hausen
Place of publication United States
Publisher Wiley-Liss, Inc.
Collection year 2003
Language eng
Subject C1
321202 Epidemiology
730204 Child health
Abstract Limited population-based epidemiologic information is available on Ewing's sarcoma family of tumours (ESFT), a rare group of neoplasms. Several associations have been noted on a few studies but results were not consistent, except for exposure to farming among cases and their parents. Here we present the non-farm findings of a nationwide case-control study of ESFT in children and young adults in Australia. The analysis included 106 persons with confirmed ESFT and 344 population-based controls selected randomly via telephone. Information was collected by interview (84% face to face). We found a strong and significant association of ESFT with hernias, in particular hernia repaired in hospital (OR = 5.6, 95% Cl 1.3-6.4). Among other factors, there was a near doubling of risk for males, and male cases had their pubertal signs earlier (started shaving earlier) than male controls. There was also an increased risk of ESFT at higher levels of self-assessed exercise, but no other factor really stood out. For pregnancy-related factors, there was a tripling of risk for glandular fever, a doubling of risk for urinary tract infection and a near doubling of risk for X-rays during or just before pregnancy, but these estimates were not significant. In addition, there was a large number of inverse associations with medical conditions (specifically bone disorders), case exposure to medications, vaccinations and X-rays, with ultrasound during the pregnancy having the most certain effects. We conclude that, although the aetiology of ESFT remains obscure, overall there is strong evidence of an association with inguinal hernia; this can now be added to the farm-associated risk reported by others and us. The other associations reported here await replication and refinement in future studies. (C) 2003 Wiley-Liss, Inc.
Keyword Oncology
Ewing's Sarcoma
Childhood Cancer
Epidemiology
Risk Factors
Hernia
Australia
Congenital Inguinal-hernia
Risk-factors
Parental Occupation
Childhood-cancer
Etiology
Q-Index Code C1

 
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