Cerebral function in posttraumatic stress disorder during verbal working memory updating: A positron emission tomography study

Clark, C.R., McFarlane, A.C., Morris, P., Weber, D.L., Sonkkilla, C., Shaw, M., Marcina, J., Tochon-Danguy, H.J. and Egan, G.F. (2003) Cerebral function in posttraumatic stress disorder during verbal working memory updating: A positron emission tomography study. Biological Psychiatry, 53 6: 474-481. doi:10.1016/S0006-3223(02)01505-6


Author Clark, C.R.
McFarlane, A.C.
Morris, P.
Weber, D.L.
Sonkkilla, C.
Shaw, M.
Marcina, J.
Tochon-Danguy, H.J.
Egan, G.F.
Title Cerebral function in posttraumatic stress disorder during verbal working memory updating: A positron emission tomography study
Journal name Biological Psychiatry   Check publisher's open access policy
ISSN 0006-3223
1873-2402
Publication date 2003-03-15
Sub-type Article (original research)
DOI 10.1016/S0006-3223(02)01505-6
Volume 53
Issue 6
Start page 474
End page 481
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2003
Language eng
Subject 321021 Psychiatry
730211 Mental health
Formatted abstract
Background:
This study examined cerebral function in posttraumatic stress disorder (PTSD) during the updating of working memory to trauma-neutral, verbal information.

Methods:
Ten PTSD and matched control subjects completed a visuoverbal target detection task involving continuous updating (Variable target condition) or no updating (Fixed target condition) of target identity, with updating activity estimated by condition comparison.

Results:
Normal updating activity using this paradigm involved bilateral activation of the dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobe. The PTSD group lacked this activation in the left hemisphere and was significantly different from control subjects in this regard, but showed additional activation in the superior parietal lobe, bilaterally.

Conclusions:
The pattern of parietal activation suggests a dependence on visuospatial coding for working memory representation of trauma-neutral, verbal information. Group differences in the relative involvement of the DLPFC indicate less dependence in PTSD on the executive role normally attributed to the left DLPFC for monitoring and manipulation of working memory content in posterior regions of the brain.
Keyword Neurosciences
Psychiatry
Posttraumatic Stress Disorder
Working Memory
Positron Emission Tomography
Frontal-parietal Axis
Cortical networks
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes online 12 March 2003.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 02:49:34 EST