Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection

Sousa-Nunes, R., Rana, A. A., Kettleborough, R., Brickman, J. M., Clements, M., Forrest, A., Grimmond, S., Avner, P., Smith, J. C. and Dunwoodie, S. L. (2003) Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Genome Research, 13 12: 2609-2620. doi:10.1101/gr1362303

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Author Sousa-Nunes, R.
Rana, A. A.
Kettleborough, R.
Brickman, J. M.
Clements, M.
Forrest, A.
Grimmond, S.
Avner, P.
Smith, J. C.
Dunwoodie, S. L.
Title Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection
Journal name Genome Research   Check publisher's open access policy
ISSN 1088-9051
1549-5469
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1101/gr1362303
Open Access Status File (Publisher version)
Volume 13
Issue 12
Start page 2609
End page 2620
Total pages 12
Place of publication Cold Spring Harbor, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Collection year 2003
Language eng
Abstract This article investigates the expression patterns of 160 genes that are expressed during early mouse development. The cDNAs were isolated from 7.5 d postcoitum (dpc) encloderm, a region that comprises visceral encloderm (VE), definitive encloderm, and the node-tissues that are required for the initial steps of axial specification and tissue patterning in the mouse. To avoid examining the same gene more than once, and to exclude potentially ubiquitously expressed housekeeping genes, cDNA sequence was derived from 1978 clones of the Endoderm library. These yielded 1440 distinct cDNAs, of which 123 proved to be novel in the mouse. In situ hybridization analysis was carried out on 160 of the cDNAs, and of these, 29 (18%) proved to have restricted expression patterns.
Keyword Biochemistry & Molecular Biology
Biotechnology & Applied Microbiology
Genetics & Heredity
Tyrosine-phosphatase-sigma
Townes-brocks-syndrome
Genome Sequence
Murine Homolog
Mice Lacking
Stem-cells
Embryogenesis
Protein
Defects
Sall1
Q-Index Code C1
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 12:48:02 EST