Event-related potential correlates of impaired visuospatial working memory in schizophrenia

Cameron, Allison M., Geffen, Gina M., Kavanagh, David J., Wright, Margie J., McGrath, John J. and Geffen, Laurie B. (2003) Event-related potential correlates of impaired visuospatial working memory in schizophrenia. Psychophysiology, 40 5: 702-715. doi:10.1111/1469-8986.00071

Author Cameron, Allison M.
Geffen, Gina M.
Kavanagh, David J.
Wright, Margie J.
McGrath, John J.
Geffen, Laurie B.
Title Event-related potential correlates of impaired visuospatial working memory in schizophrenia
Journal name Psychophysiology   Check publisher's open access policy
ISSN 0048-5772
Publication date 2003
Sub-type Article (original research)
DOI 10.1111/1469-8986.00071
Volume 40
Issue 5
Start page 702
End page 715
Total pages 14
Editor Gregory A. Miller
et al.
Place of publication Massachusetts
Publisher Blackwell
Collection year 2003
Language eng
Abstract Previous studies have reported that patients with schizophrenia demonstrate impaired performance during working memory (WM) tasks. The current study aimed to determine whether WM impairments in schizophrenia are accompanied by reduced slow wave (SW) activity during on-line maintenance of mnemonic information. Event-related potentials were obtained from patients with schizophrenia and well controls as they performed a visuospatial delayed response task. On 50% of trials, a distractor stimulus was introduced during the delay. Compared with controls, patients with schizophrenia produced less SW memory negativity, particularly over the right hemisphere, together with reduced frontal enhancement of SW memory negativity in response to distraction. The results indicate that patients with schizophrenia generate less maintenance phase neuronal activity during WM performance, especially under conditions of distraction.
Keyword Psychology
Psychology, Biological
Psychology, Experimental
Delayed Response Task
Working Memory
Event-related Potentials
Slow Wave
Magnetic-resonance Spectroscopy
Membrane Phospholipid-metabolism
Monkey Dopamine Neurons
Adult Reading Test
Prefrontal Cortex
Medicated Schizophrenics
Brain Potentials
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

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Created: Wed, 15 Aug 2007, 02:45:40 EST