A prospective trial of short-fractionation radiotherapy for the palliation of liver metastases

Bydder, S., Spry, N.A., Christie, D.R.H., Roos, D., Burmeister, B., Krawitz, H., Davis, S., Joseph, D.J., Poulsen, M. and Berry, M. (2003) A prospective trial of short-fractionation radiotherapy for the palliation of liver metastases. Australasian Radiology, 47 3: 284-288. doi:10.1046/j.1440-1673.2003.01177.x


Author Bydder, S.
Spry, N.A.
Christie, D.R.H.
Roos, D.
Burmeister, B.
Krawitz, H.
Davis, S.
Joseph, D.J.
Poulsen, M.
Berry, M.
Title A prospective trial of short-fractionation radiotherapy for the palliation of liver metastases
Journal name Australasian Radiology   Check publisher's open access policy
ISSN 0004-8461
1440-1673
Publication date 2003
Sub-type Article (original research)
DOI 10.1046/j.1440-1673.2003.01177.x
Volume 47
Issue 3
Start page 284
End page 288
Total pages 5
Editor Michael R. Sage
Place of publication Australia
Publisher Blackwell Publishing
Collection year 2003
Language eng
Subject 321023 Radiotherapy and Nuclear Medicine
730108 Cancer and related disorders
Abstract The purpose of this study was to prospectively examine the effectiveness and tolerability of a simple radiotherapy technique for the palliation of symptomatic liver metastases. Twenty-eight patients with symptomatic liver metastases were enrolled from seven centres, and received targeted (partial or whole) liver irradiation consisting of 10 Gy in two fractions over 2 days. Symptoms at baseline were hepatic pain (27 patients), abdominal distension (19), night sweats (12), nausea (18) and vomiting (eight). Twenty-two patients (76%) had failed previous treatment with chemotherapy, hormonal therapy and/or high-dose steroids. Symptoms and potential toxicities were prospectively assessed at the time of treatment, then 2, 6 and 10 weeks later. Individual symptom response rates were 53−66% at 2 weeks. Partial or complete global symptomatic responses were noted in 15 patients (54%) overall. The treatment was well tolerated with two patients (7%) experiencing grade 3 toxicity (one vomiting and one diarrhoea); however, four patients reported temporary worsening of pain shortly after treatment. This simple and well-tolerated treatment achieves useful palliation.
Q-Index Code C1
Additional Notes Article first published online: 11 August 2003

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 02:41:05 EST