Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: Worldwide emergence

Vandenesch, François, Naimi, Timothy, Enright, Mark C., Lina, Gerard, Nimmo, Graeme R., Heffernan, Helen, Liassine, Nadia, Bes, Michèle, Greenland, Timothy, Reverdy, Marie-Elisabeth and Etienne, Jerome (2003) Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: Worldwide emergence. Emerging Infectious Diseases, 9 8: 978-984. doi:10.3201/eid0908.030089


Author Vandenesch, François
Naimi, Timothy
Enright, Mark C.
Lina, Gerard
Nimmo, Graeme R.
Heffernan, Helen
Liassine, Nadia
Bes, Michèle
Greenland, Timothy
Reverdy, Marie-Elisabeth
Etienne, Jerome
Title Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: Worldwide emergence
Formatted title
Community-Acquired Methicillin-Resistant Staphylococcus aureus Carrying Panton-Valentine Leukocidin Genes: Worldwide Emergence
Journal name Emerging Infectious Diseases   Check publisher's open access policy
ISSN 1080-6040
Publication date 2003-08
Sub-type Article (original research)
DOI 10.3201/eid0908.030089
Open Access Status DOI
Volume 9
Issue 8
Start page 978
End page 984
Total pages 7
Editor Peter Drotman
Place of publication Atlanta, United States
Publisher US National Centre for Infectious Diseases
Collection year 2003
Language eng
Subject C1
320401 Medical Bacteriology
730101 Infectious diseases
Abstract Infections caused by community-acquired (CA)-methicillin-resistant Staphylococcus aureus (MRSA) have been reported worldwide. We assessed whether any common genetic markers existed among 117 CA-MRSA isolates from the United States, France, Switzerland, Australia, New Zealand, and Western Samoa by performing polymerase chain reaction for 24 virulence factors and the methicillin-resistance determinant. The genetic background of the strain was analyzed by pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). The CA-MRSA strains shared a type IV SCCmec cassette and the Panton-Valentine leukocidin locus, whereas the distribution of the other toxin genes was quite specific to the strains from each continent. PFGE and MLST analysis indicated distinct genetic backgrounds associated with each geographic origin, although predominantly restricted to the agr3 background. Within each continent, the genetic background of CA-MRSA strains did not correspond to that of the hospital-acquired MRSA.
Keyword Immunology
Infectious Diseases
Gel-electrophoresis
Infections
Pneumonia
Clones
Identification
Gentamicin
Australia
Mrsa
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 02:38:18 EST