Cardiac function in fetuses of poorly-controlled pre-gestational diabetic pregnancies - a pilot study

Wong, S.F., Chan, F. Y., Cincotta, R., McIntyre, H. D. and Oats, J. (2003) Cardiac function in fetuses of poorly-controlled pre-gestational diabetic pregnancies - a pilot study. Gynecologic and Obstetric Investigation, 56 2: 113-116. doi:10.1159/000073191

Author Wong, S.F.
Chan, F. Y.
Cincotta, R.
McIntyre, H. D.
Oats, J.
Title Cardiac function in fetuses of poorly-controlled pre-gestational diabetic pregnancies - a pilot study
Journal name Gynecologic and Obstetric Investigation   Check publisher's open access policy
ISSN 0378-7346
Publication date 2003
Sub-type Article (original research)
DOI 10.1159/000073191
Volume 56
Issue 2
Start page 113
End page 116
Total pages 4
Editor T. O'Hooghe
Place of publication Switzerland
Publisher S Karger AG
Collection year 2003
Language eng
Subject C1
730116 Reproductive system and disorders
111402 Obstetrics and Gynaecology
1114 Paediatrics and Reproductive Medicine
Abstract Objective: Cardiac impairment is frequently found in babies of diabetic mothers. It is still controversial whether this is due to poor glucose control. The aim of this study is to compare the cardiac function in fetuses of well- and poorly-controlled pre-gestational diabetic pregnancy in third trimester. Methods:Women with type 1 pre-gestational diabetes were enrolled at 30-32 weeks. Cardiac size and interventricular septal wall thickness were measured by M-mode at end-diastolic phase. The right and left ventricular ejection fractions were calculated. At the mitral and tricuspid valves inflow, the ratio between early ventricular filling and active atrial filling (E/A) at both atrioventricular valves were measured by Doppler echocardiography. Peak velocities of ascending aorta and pulmonary artery were assessed. The angle of isonation was kept at <20degrees. Women with poorly-controlled diabetes (HbA1c >6.5%) were compared with those with satisfactorily controlled diabetes (HbA1c less than or equal to 6.5%). Results: A total of 21 women with pre-gestational diabetes were recruited for this study. Eight women with well-controlled diabetes were compared with 9 women who had poorly-controlled diabetes. HbA1c in the poorly-controlled group was 7.3% and in the well-controlled group it was 5.4% (p < 0.001). There was no difference between the two groups in cardiac size, interventricular septal wall thickness, ejection fraction, aorta and pulmonary artery peak flow velocities. The right atrioventricular E/A ratio was significantly lower among the poorly-controlled diabetic pregnancies (0.71 vs. 0.54; p < 0.05). Conclusion: Fetuses of poorly-controlled diabetic mothers had a lower right atrioventricular E/A ratio. This may be due to metabolic acidosis, non-hypertrophic cardiac dysfunction or fetal polycythemia. Copyright (C) 2003 S. Karger AG, Basel.
Keyword Diabetes, Aspects
Pre-gestational Diabetic Pregnancies
Pregnancy Medical Disorders
High-risk Obstetrics
Pregnancy Care
Cardiac Dysfunction
Fetal Ultrasound
Hypertrophic Cardiomyopathy
Q-Index Code C1

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 02:34:27 EST