Homocysteine and cardiovascular disease in renal disease

Austen, S. K., Coombes, J. S. and Fassett, R. G. (2003) Homocysteine and cardiovascular disease in renal disease. Nephrology, 8 6: 285-295. doi:10.1111/j.1440-1797.2003.00210.x

Author Austen, S. K.
Coombes, J. S.
Fassett, R. G.
Title Homocysteine and cardiovascular disease in renal disease
Journal name Nephrology   Check publisher's open access policy
ISSN 1320-5358
Publication date 2003
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1440-1797.2003.00210.x
Volume 8
Issue 6
Start page 285
End page 295
Total pages 11
Editor G. Becker
Place of publication Carlton, Vic.
Publisher Blackwell Publishing
Collection year 2003
Language eng
Subject C1
321012 Nephrology and Urology
730115 Urogenital system and disorders
Abstract Elevated homocysteine (hyperhomocysteinaemia) in renal patients is a major concern for physicians. Although cause and effect between homocysteine and cardiovascular disease (CVD) has not been established in either the general population or renal patients, there is much evidence that this relationship does exist. Purported mechanisms that may explain this effect include increases in endothelial injury, smooth muscle cell proliferation, low-density lipoprotein oxidation and changes in haemostatic balance. Renal patients have a much greater incidence of hyperhomocysteinaemia and this may be explained by decreases in either the renal or extrarenal metabolism of the compound. We conclude that data from long-term placebo-controlled trials are urgently required to determine whether hyperhomocysteinaemia in renal patients is a cause of CVD events and requires therapeutic targeting.
Keyword Urology & Nephrology
Cardiovascular Disease
Cyclosporine A
Folic Acid
Renal Disease
Renal Transplant Recipients
Vitamin B-6
Vitamin B12
Maintenance Dialysis Patients
Serum Total Homocysteine
Vascular Smooth-muscle
Cereal Grain Flour
Transplant Recipients
Plasma Homocysteine
Q-Index Code C1
Additional Notes This document is a journal review.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Human Movement and Nutrition Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 02:30:57 EST