1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons

Brown, Jillanne, Bianco, John I., McGrath, John J. and Eyles, Darryl W. (2003) 1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neuroscience Letters, 343 2: 139-143. doi:10.1016/S0304-3940(03)00303-3


Author Brown, Jillanne
Bianco, John I.
McGrath, John J.
Eyles, Darryl W.
Title 1,25-Dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 2003-01-01
Sub-type Article (original research)
DOI 10.1016/S0304-3940(03)00303-3
Volume 343
Issue 2
Start page 139
End page 143
Total pages 5
Editor Manfred Zimmermann
Place of publication Amsterdam
Publisher Elsevier
Collection year 2003
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
320799 Neurosciences not elsewhere classified
780105 Biological sciences
Formatted abstract
There is an accumulation of evidence implicating a role for vitamin D-3 in the developing brain. The receptor for this seco-steroid is expressed in both neurons and glial cells, it induces nerve growth factor (NGF) and it is a potent inhibitor of mitosis and promoter of differentiation in numerous cells. We have therefore assessed the direct effect of vitamin D-3 on mitosis, neurite outgrowth, as well as NGF production as a possible mediator of those effects, in developing neurons. Using cultured embryonic hippocampal cells and explants we found the addition of vitamin D-3 significantly decreases the percentage of cultured hippocampal cells undergoing mitosis in conjunction with increases in both neurite outgrowth and NGF production. The role of vitamin D-3 during brain development warrants closer scrutiny. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
Keyword Neurosciences
1,25-dihydroxyvitamin D-3
Nerve Growth Factor
Hippocampus
Tissue Culture
Brain Development
Mitosis
Calcium-regulating Hormones
Neurotrophin Receptor
Messenger-rna
Expression
Cells
Pregnancy
System
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 12:18:14 EST