An investigation of the 5-HT2C receptor gene as a migraine candidate gene

Johnson, MP, Lea, RA, Curtain, RP, MacMillan, JC and Griffiths, LR (2003) An investigation of the 5-HT2C receptor gene as a migraine candidate gene. American Journal of Medical Genetics Part B-neuropsychiatric Genetics, 117B 1: 86-89. doi:10.1002/ajmg.b.10007


Author Johnson, MP
Lea, RA
Curtain, RP
MacMillan, JC
Griffiths, LR
Title An investigation of the 5-HT2C receptor gene as a migraine candidate gene
Journal name American Journal of Medical Genetics Part B-neuropsychiatric Genetics   Check publisher's open access policy
ISSN 0148-7299
Publication date 2003
Sub-type Article (original research)
DOI 10.1002/ajmg.b.10007
Volume 117B
Issue 1
Start page 86
End page 89
Total pages 4
Editor J. C. Carey
M.T. Tsuang
S.V. Faraone
Place of publication Hoboken, U.S.A.
Publisher John Wiley & Sons
Collection year 2003
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an X-linked genetic component. Recent studies have identified an X chromosomal susceptibility region (Xq24-q28) in two typical migraine pedigrees. This region harbours a potential candidate gene for the disorder, the serotonin receptor 2C (5-HT2C) gene. This study involved a linkage and association approach to investigate two single nucleotide variants in the 5-HT2C gene. In addition, exonic coding regions of the 5-HT2C gene were also sequenced for mutations in X-linked migraine pedigrees. Results of this study did not detect any linkage or association, and no disease causing mutations were identified. Hence, results for this study do not support a significant role of the 5-HT2C gene in migraine predisposition. (C) 2003 Wiley-Liss, Inc.
Keyword Genetics & Heredity
Psychiatry
Migraine
Linkage
Association
5-ht2c
Familial Typical Migraine
United-states
Headache
Aura
Prevalence
5-hydroxytryptamine
Identification
Localization
Population
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2004 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 02:13:22 EST