Ca2+-activated K+(BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala

Faber, E. S. L. and Sah, P. (2003) Ca2+-activated K+(BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. Journal of Physiology, 552 2: 483-497. doi:10.1113/jphysiol.2003.050120


Author Faber, E. S. L.
Sah, P.
Title Ca2+-activated K+(BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala
Formatted title
Ca2+ -activated K+ (BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala
Journal name Journal of Physiology   Check publisher's open access policy
ISSN 0022-3751
Publication date 2003
Sub-type Article (original research)
DOI 10.1113/jphysiol.2003.050120
Volume 552
Issue 2
Start page 483
End page 497
Total pages 15
Editor David Attwell
Place of publication USA
Publisher Cambridge University Press
Collection year 2003
Language eng
Subject C1
320702 Central Nervous System
730104 Nervous system and disorders
Abstract In many neurons, trains of action potentials show frequency-dependent broadening. This broadening results from the voltage-dependent inactivation of K+ currents that contribute to action potential repolarisation. In different neuronal cell types these K+ currents have been shown to be either slowly inactivating delayed rectifier type currents or rapidly inactivating A-type voltage-gated K+ currents. Recent findings show that inactivation of a Ca2+-dependent K+ current, mediated by large conductance BK-type channels, also contributes to spike broadening. Here, using whole-cell recordings in acute slices, we examine spike broadening in lateral amygdala projection neurons. Spike broadening is frequency dependent and is reversed by brief hyperpolarisations. This broadening is reduced by blockade of voltage-gated Ca2+ channels and BK channels. In contrast, broadening is not blocked by high concentrations of 4-aminopyridine (4-AP) or alpha-dendrotoxin. We conclude that while inactivation of BK-type Ca2+-activated K+ channels contributes to spike broadening in lateral amygdala neurons, inactivation of another as yet unidentified outward current also plays a role.
Keyword Physiology
Hippocampal Pyramidal Neurons
Action-potential Repolarization
Activated Potassium Currents
Long-term Potentiation
Outside-out Patches
Squid Giant Synapse
Electrophysiological Properties
After-hyperpolarization
Transmitter Release
Presynaptic Calcium
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 02:04:30 EST