Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo

Forger, NG, Prevette, D, deLapeyriere, O, de Bovis, B, Wang, SW, Bartlett, P and Oppenheim, RW (2003) Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. Journal of Neuroscience, 23 26: 8854-8858.

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Author Forger, NG
Prevette, D
deLapeyriere, O
de Bovis, B
Wang, SW
Bartlett, P
Oppenheim, RW
Title Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2003
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 23
Issue 26
Start page 8854
End page 8858
Total pages 5
Place of publication USA
Publisher Society for Neuroscience
Collection year 2003
Language eng
Subject C1
320704 Cellular Nervous System
730104 Nervous system and disorders
Abstract The ciliary neurotrophic factor alpha-receptor(CNTFRalpha) is required for motoneuron survival during development, but the relevant ligand(s) has not been determined. One candidate is the heterodimer formed by cardiotrophin-like cytokine (CLC) and cytokine-like factor 1 (CLF). CLC/CLF binds to CNTFRalpha and enhances the survival of developing motoneurons in vitro; whether this novel trophic factor plays a role in neural development in vivo has not been tested. We examined motor and sensory neurons in embryonic chicks treated with CLC and in mice with a targeted deletion of the clf gene. Treatment with CLC increased the number of lumbar spinal cord motoneurons that survived the cell death period in chicks. However, this effect was regionally specific, because brachial and thoracic motoneurons were unaffected. Similarly, newborn clf -/- mice exhibited a significant reduction in lumbar motoneurons, with no change in the brachial or thoracic cord. Clf deletion also affected brainstem motor nuclei in a regionally specific manner; the number of motoneurons in the facial but not hypoglossal nucleus was significantly reduced. Sensory neurons of the dorsal root ganglia were not affected by either CLC treatment or clf gene deletion. Finally, mRNA for both clc and clf was found in skeletal muscle fibers of embryonic mice during the motoneuron cell death period. These findings support the view that CLC/CLF is a target-derived factor required for the survival of specific pools of motoneurons. The in vivo actions of CLC and CLF can account for many of the effects of CNTFRalpha on developing motoneurons.
Keyword Neurosciences
Motoneuron
Cell Death
Trophic Factor
Cardiotrophin
Cytokine
Ciliary Neurotrophic Factor
Factor-receptor-alpha
Programmed Cell-death
Motor-neurons
Mice Lacking
Embryonic Motoneurons
Survival Factor
Cntf Receptor
Chick-embryo
Expression
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 02:04:18 EST