Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids

Cryle, M. J., Matovic, N. J. and De Voss, J. J. (2003) Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids. Organic Letters, 5 18: 3341-3344. doi:10.1021/ol035254e

Author Cryle, M. J.
Matovic, N. J.
De Voss, J. J.
Title Products of Cytochrome P450BioI (CYP107H1)-Catalyzed Oxidation of Fatty Acids
Formatted title
Products of cytochrome P450Biol (CYP107H1) -catalyzed oxidation of fatty acids
Journal name Organic Letters   Check publisher's open access policy
ISSN 1523-7060
Publication date 2003
Sub-type Article (original research)
DOI 10.1021/ol035254e
Volume 5
Issue 18
Start page 3341
End page 3344
Total pages 4
Place of publication Washington DC
Publisher American Chemical Society
Collection year 2003
Language eng
Subject C1
270108 Enzymes
780103 Chemical sciences
Abstract [GRAPHICS] Oxidation of tetradecanoic and hexadecanoic acids by cytochrome P450(Biol) (CYP107H1) produces mainly the 11-, 12-, and 13-hydroxy C-14 fatty acids and the 11- to 15-hydroxy C-16 fatty acids, respectively. In contrast to previous reports, terminal hydroxylation is not observed. The enantiospecificity of fatty acid hydroxylation by P450(Biol) was also determined, and the enzyme was shown to be moderately selective for production of the (R)-alcohols.
Keyword Chemistry, Organic
Chromatography Mass-spectrometry
Q-Index Code C1

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Created: Wed, 15 Aug 2007, 01:56:00 EST