Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde

Bernhardt, P. V., Caldwell, L., Lovejoy, D. and Richardson, D. R. (2003) Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde. Acta Crystallographica Section C: Crystal Structure Communications, 59 11: o629-o633. doi:10.1107/S0108270103021401

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Author Bernhardt, P. V.
Caldwell, L.
Lovejoy, D.
Richardson, D. R.
Title Four cytotoxic N4-substituted thiosemicarbazones derived from 2-hydroxynaphthalene-1-carboxaldehyde
Journal name Acta Crystallographica Section C: Crystal Structure Communications   Check publisher's open access policy
ISSN 0108-2701
Publication date 2003-11
Year available 2003
Sub-type Article (original research)
DOI 10.1107/S0108270103021401
Open Access Status File (Publisher version)
Volume 59
Issue 11
Start page o629
End page o633
Total pages 5
Place of publication Copenhagan, Denmark
Publisher Blackwell Munksgaard
Collection year 2003
Language eng
Subject C1
250105 Structural Chemistry
780103 Chemical sciences
Abstract The X-ray crystal structures are reported of four novel and potentially O,N,S-tridentate donor ligands that demonstrate antitumour activity. These ligands are 1-[(4-methylthiosemicarbazono)methyl]-2-naphthol, C13H13N3OS, (III), 1-[(4-ethylthiosemicarbazono)methyl]-2-naphthol, C14H15N3OS, (IV), 1-[(4-phenylthiosemicarbazono)methyl]-2-naphthol, C18H15N3OS, (V), and 1-[(4,4-dimethylthiosemicarbazono)methyl]-2-naphthol dimethyl sulfoxide solvate, C14H15N3OS.C2H6OS, (VI). These chelators are N4-substituted thiosemicarbazones, each based on the same parent aldehyde, namely 2-zhydroxynaphthalene-1-carboxaldehyde isonicotinoylhydrazone. Conformational variations within this series are discussed in relation to the optimum conformation for metal-ion binding.
Keyword Crystallography
Iron Chelators
Q-Index Code C1
Institutional Status UQ

 
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Created: Wed, 15 Aug 2007, 01:50:00 EST