OxyR acts as a repressor of catalase expression in Neisseria gonorrhoeae

Tseng, Hsing-Ju, McEwan, Alastair G., Apicella, Michael A. and Jennings, Michael P. (2003) OxyR acts as a repressor of catalase expression in Neisseria gonorrhoeae. Infection and Immunity, 71 1: 550-556. doi:10.1128/IAI.71.1.550-556.2003

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Author Tseng, Hsing-Ju
McEwan, Alastair G.
Apicella, Michael A.
Jennings, Michael P.
Title OxyR acts as a repressor of catalase expression in Neisseria gonorrhoeae
Journal name Infection and Immunity   Check publisher's open access policy
ISSN 1098-5522
Publication date 2003-01
Sub-type Article (original research)
DOI 10.1128/IAI.71.1.550-556.2003
Open Access Status File (Publisher version)
Volume 71
Issue 1
Start page 550
End page 556
Total pages 7
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2003
Language eng
Abstract It has been reported that Neisseria gonorrhoeae possesses a very high level of catalase activity, but the regulation of catalase expression has not been investigated extensively. In Escherichia coli and Salmonella enterica serovar Typhimurium, it has been demonstrated that OxyR is a positive regulator of hydrogen peroxide-inducible genes, including the gene encoding catalase. The oxyR gene from N. gonorrhoeae was cloned and used to complement an E. coli oxyR mutant, confirming its identity and function. The gene was inactivated by inserting a kanamycin resistance cassette and used to make a knockout allele on the chromosome of N. gonorrhoeae strain 1291. In contrast to E. coli, the N. gonorrhoeae oxyR::kan mutant expressed ninefold-more catalase activity and was more resistant to hydrogen peroxide killing than the wild type. These data are consistent with OxyR in N. gonorrhoeae acting as a repressor of catalase expression.
Keyword Immunology
Infectious Diseases
Oxidative Stress
Q-Index Code C1
Institutional Status UQ

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Created: Wed, 15 Aug 2007, 01:47:51 EST