Balancing the number and size of sites: An economic approach to the optimal design of cluster samples

Connelly, L. B. (2003) Balancing the number and size of sites: An economic approach to the optimal design of cluster samples. Controlled Clinical Trials, 24 5: 544-559. doi:10.1016/S0197-2456(03)00093-X


Author Connelly, L. B.
Title Balancing the number and size of sites: An economic approach to the optimal design of cluster samples
Journal name Controlled Clinical Trials   Check publisher's open access policy
ISSN 0197-2456
Publication date 2003
Sub-type Article (original research)
DOI 10.1016/S0197-2456(03)00093-X
Volume 24
Issue 5
Start page 544
End page 559
Total pages 16
Editor K.B. Drennan
Place of publication New York, U.S.A.
Publisher Elsevier
Collection year 2003
Language eng
Subject C1
340204 Health Economics
720299 Microeconomic issues not elsewhere classified
11 Medical and Health Sciences
1103 Clinical Sciences
Abstract The design of randomized controlled trials entails decisions that have economic as well as statistical implications. In particular, the choice of an individual or cluster randomization design may affect the cost of achieving the desired level of power, other things being equal. Furthermore, if cluster randomization is chosen, the researcher must decide how to balance the number of clusters, or sites, and the size of each site. This article investigates these interrelated statistical and economic issues. Its principal purpose is to elucidate the statistical and economic trade-offs to assist researchers to employ randomized controlled trials that have desired economic, as well as statistical, properties. (C) 2003 Elsevier Inc. All rights reserved.
Keyword Cluster Sample
Design
Economic Analysis
Medicine, Research & Experimental
Optimal Design
Pharmacology & Pharmacy
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 01:43:54 EST