Nutritional effects on neuron numbers

Bedi, K.S. (2003) Nutritional effects on neuron numbers. Nutritional Neuroscience, 6 3: 141-152. doi:10.1080/1028415031000098549

Author Bedi, K.S.
Title Nutritional effects on neuron numbers
Journal name Nutritional Neuroscience   Check publisher's open access policy
ISSN 1028-415X
Publication date 2003-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1080/1028415031000098549
Volume 6
Issue 3
Start page 141
End page 152
Total pages 12
Place of publication United Kingdom
Publisher Taylor and Francis
Collection year 2003
Language eng
Subject C1
270106 Cell Development (incl. Cell Division and Apoptosis)
730104 Nervous system and disorders
Abstract Undemutrition during early life is known to cause deficits and distortions of brain structure although it has remained uncertain whether or not this includes a diminution of the total numbers of neurons. Estimates of numerical density (e.g. number of cells per microscopic field, or number of cells per unit area of section, or number of cells per unit volume of tissue) are extremely difficult to interpret and do not provide estimates of total numbers of cells. However, advances in stereological techniques have made it possible to obtain unbiased estimates of total numbers of cells in well defined biological structures. These methods have been utilised in studies to determine the effects of varying periods of undernutrition during early life on the numbers of neurons in various regions of the rat brain. The regions examined so far have included the cerebellum, the dentate gyrus, the olfactory bulbs and the cerebral cortex. The only region to show, unequivocally, that a period of undernutrition during early life causes a deficit in the number of neurons was the dentate gyrus. These findings are discussed in the context of other morphological and functional deficits present in undernourished animals.
Keyword Malnutrition
Olfactory Lobes
Nutrition & Dietetics
Early Postnatal Life
Rat Olfactory-bulb
Granule Cells
Cerebellar Cortex
Stereological Analysis
Early Undernutrition
Q-Index Code C1

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: 2004 Higher Education Research Data Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 26 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 01:43:24 EST