Cerebral impedance and neurological outcome following a mild or severe hypoxic/ischemic episode in neonatal piglets

Lingwood, B. E., Dunster, K. R., Healy, G. N., Ward, L. C. and Colditz, P. B. (2003) Cerebral impedance and neurological outcome following a mild or severe hypoxic/ischemic episode in neonatal piglets. Brain Research, 969 1-2: 160-167. doi:10.1016/S0006-8993(03)02295-9

Author Lingwood, B. E.
Dunster, K. R.
Healy, G. N.
Ward, L. C.
Colditz, P. B.
Title Cerebral impedance and neurological outcome following a mild or severe hypoxic/ischemic episode in neonatal piglets
Journal name Brain Research   Check publisher's open access policy
ISSN 0006-8993
Publication date 2003
Sub-type Article (original research)
DOI 10.1016/S0006-8993(03)02295-9
Volume 969
Issue 1-2
Start page 160
End page 167
Total pages 8
Editor F. E. Bloom
Place of publication Amsterdam
Publisher Elsevier BV
Collection year 2003
Language eng
Subject C1
321019 Paediatrics
730104 Nervous system and disorders
Abstract Multi-frequency bio-impedance has the potential to identify infants at risk of poor neurodevelopmental outcome following hypoxia by detecting cerebral edema. This study investigated the relationship between the severity of an hypoxic/ischemic episode, neurological outcome following the hypoxia and non-invasively measured cerebral bioelectrical impedance in piglets. One-day-old piglets were anaesthetised and ventilated. Hypoxia was induced by reducing the inspired oxygen concentration to 3-5%. Severe hypoxia was defined as hypoxia resulting in at least 30 min of low amplitude EEG (<5 muV) as well as hypotension and acidosis. Cerebral bio-impedance was measured before, during and for up to 6 h post-hypoxia. Neurological outcome was determined by a neurology score at 24 and 48 h after hypoxia, and by histological examination of the brain at 72 h. There was no increase in cerebral impedance in control animals. Following mild hypoxia cerebral impedance increased transiently. Following severe hypoxia, cerebral impedance increased and remained elevated. Cerebral impedance following severe hypoxia was significantly higher than after mild hypoxia at 10 min and from 2 to 6 h after resuscitation. Cerebral impedance measurements made up to I h and between 3 and 6 It after resuscitation were significantly correlated with neurological outcome. Results indicate that non-invasive cerebral impedance measurements are able to discriminate early between those individuals who have suffered a mild, acute hypoxic episode, and those who have suffered a severe hypoxic episode. The technique has the potential to predict which individuals will have a poor neurological outcome. (C) 2003 Elsevier Science B.V. All rights reserved.
Keyword Neurosciences
Brain Edema
Electric Impedance
Neurological Outcome
Total-body Water
Frequency Bioelectrical-impedance
Hypoxic-ischemic Encephalopathy
Survival Model
Birth Asphyxia
Term Infants
Q-Index Code C1
Additional Notes This paper demonstrates that cerebral impedance measurements have the potential to predict the severity of neurological injury with 6 hours of birth following perinatal asphyxia. Number of citations on Science Citation Index = 3

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Created: Wed, 15 Aug 2007, 01:42:00 EST