Gender differences in CF phenotype associated with low bone mineral density

Greer, R., Bell, S. C., O'Rourke, P., Buntain, H., Batch, J. and Francis, P. (2003). Gender differences in CF phenotype associated with low bone mineral density. In: Journal of Cystic Fibrosis. Proceedings of 26th Congress ECFS. 26th European CF Conference, Belfast, Ireland, (S76-S76). June 5–7 2003. doi:10.1016/S1569-1993(03)00027-4


Author Greer, R.
Bell, S. C.
O'Rourke, P.
Buntain, H.
Batch, J.
Francis, P.
Title of paper Gender differences in CF phenotype associated with low bone mineral density
Conference name 26th European CF Conference
Conference location Belfast, Ireland
Conference dates June 5–7 2003
Proceedings title Journal of Cystic Fibrosis. Proceedings of 26th Congress ECFS   Check publisher's open access policy
Place of Publication The Netherlands
Publisher Elsevier
Publication Year 2003
Sub-type Published abstract
DOI 10.1016/S1569-1993(03)00027-4
ISSN 1569-1993
Volume 2
Issue Supplement 1
Start page S76
End page S76
Total pages 1
Language eng
Abstract/Summary Adolescents and adults with CF have lower bone mineral density (BMD) than normal, but its relationship with phenotype is not well understood. Point FEV1% predicted (FEV) and rate of change of FEV are biased estimates of disease severity, because progressively older subjects represent a selected survivor population, with females at greater risk of death than males. To investigate the relationship between BMD and phenotype we used an index (predicted age at death) derived from Bayesian estimates of slope and intercept of FEV, age at last measurement and survival status. Predictive equations for the index were derived from 97 subjects (78 survivors) from the RCH CF clinic, and applied to a group of 102 comparable subjects who had BMD measured, classified as having‘mild’ ()75th), ‘moderate’ (25– 75th), or ‘severe’ (-25th centile) phenotype. Total body (TB) and lumbar spine (LS) BMD z-scores (Z) were compared, adjustingfor gender effects, using 2-way ANOVA. Annual mean change in FEV segregated, as expected, according to phenotype, ‘severe’ (ns25), ‘moderate’ (ns51) and ‘mild’ (ns25) y3.01(y3.73 to y2.30)%, y0.85(y1.36 to y0.35)%, 2.70(1.92 to 3.46)%, respectively, with no gender difference. LS and TB BMDZ were different in each phenotype (P-s 0.002), LS BMDZ for ‘severe’, ‘moderate’ and ‘mild’ y1.63(CI: y2.07 to y 1.19), y0.86(CI: y1.17 to y0.55), y0.06(CI: y0.54 to 0.41). Males had lower LS BMDZ than females overall (y1.22 (CI: y1.54 to y0.91) vs. y0.48(CI: y 0.84 to y0.12) Ps0.002). In the ‘severe’ group, males had lower TB BMDZ and LS BMDZ (PF0.002). Low BMD is associated with ‘moderate’ and ‘severe’ phenotypes, with relative preservation in females in the ‘severe’ group. Female biology (reproductive fitness) might promote resistance to bone resorption at a critical level of BMD loss.
Subjects CX
321027 Respiratory Diseases
730110 Respiratory system and diseases (incl. asthma)
Q-Index Code CX
Additional Notes Article number: 296

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 01:41:38 EST