Differences in lung function, growth parameters and frequency of hospital admissions between adolescents with cystic fibrosis-related diabetes and controls

Matson, A., McMahon, S., Bell, S. C., Batch, J. and Francis, P. (2003). Differences in lung function, growth parameters and frequency of hospital admissions between adolescents with cystic fibrosis-related diabetes and controls. In: Proceedings of 26th Congress ECFS. 26th European CF Conference, Belfast, Ireland, (S54-S54). June 5–7 2003. doi:10.1016/S1569-1993(03)00027-4


Author Matson, A.
McMahon, S.
Bell, S. C.
Batch, J.
Francis, P.
Title of paper Differences in lung function, growth parameters and frequency of hospital admissions between adolescents with cystic fibrosis-related diabetes and controls
Conference name 26th European CF Conference
Conference location Belfast, Ireland
Conference dates June 5–7 2003
Proceedings title Proceedings of 26th Congress ECFS   Check publisher's open access policy
Journal name Journal of Cystic Fibrosis   Check publisher's open access policy
Place of Publication The Netherlands
Publisher Elsevier
Publication Year 2003
Sub-type Published abstract
DOI 10.1016/S1569-1993(03)00027-4
ISSN 1569-1993
Volume 2
Issue Supplement 1
Start page S54
End page S54
Total pages 1
Language eng
Abstract/Summary As survival of patients with CF increases,glucose intolerance and cystic fibrosisrelated diabetes (CFRD),ar e increasingly recognised common complications. CFRD may be preceded by a pre-diabetic state. Using markers identified as being associated with CFRD may improve targeted screening. Aim: To identify features consistently predicting CFRD in paediatric patients. Patients diagnosed with CFRD between January 1997–January 2002 were compared with age and sex matched controls. Clinical,micr obiological, and hospitalisation data was collected at time of CFRD diagnosis,and at six monthly intervals for 3 yr prior to diagnosis. Eight patients with CFRD were identified,mean age 13.7 yr (S.D. 3.49) at time of diagnosis. Control patients underwent OGTT to ensure normal glucose tolerance. Patients with CFRD had a lower FEV1 up to 12 months prior to diagnosis however, this was only significant at diagnosis. There was no difference in weight and height z scores between the 2 groups; however,the decrease in weight and height z scores in the CFRD group over 3 yr prior to diagnosis was significant. Mean number of days in hospital and admissions per patient significantly increased in the CFRD group,6 months prior to diagnosis. No other significant differences were observed between the 2 groups. Conclusions: This study has shown a difference in lung function,gr owth parameters and frequency of hospital admissions between patients with CFRD and controls. These differences may be utilised as tools for targeted screening in the paediatricyadolescent population. Further larger scale studies are required to improve guidelines for targeted screening in this population.
Subjects CX
321027 Respiratory Diseases
730110 Respiratory system and diseases (incl. asthma)
Q-Index Code CX
Additional Notes Article number: 203

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 01:41:36 EST