Presence of epidemic Pseudomonas aeruginosa shared between paediatric and adult cystic fibrosis

O'Carroll, M. R., Bell, S. C., Coulter, C., Wainwright, C. E., Nissen, M., Sloots, T. and Syrmis, M. (2003). Presence of epidemic Pseudomonas aeruginosa shared between paediatric and adult cystic fibrosis. In: P. J. Thompson, Respirology. TSANZ 2003 Annual Scientific Meeting, Adelaide, Australia, (A12-A12). 4-9 April, 2003. doi:10.1111/j.1440-1843.2003.supp_1.x

Author O'Carroll, M. R.
Bell, S. C.
Coulter, C.
Wainwright, C. E.
Nissen, M.
Sloots, T.
Syrmis, M.
Title of paper Presence of epidemic Pseudomonas aeruginosa shared between paediatric and adult cystic fibrosis
Conference name TSANZ 2003 Annual Scientific Meeting
Conference location Adelaide, Australia
Conference dates 4-9 April, 2003
Proceedings title Respirology   Check publisher's open access policy
Place of Publication Carlton South, Australia
Publication Year 2003
Sub-type Oral presentation
DOI 10.1111/j.1440-1843.2003.supp_1.x
ISSN 1323-7799
Editor P. J. Thompson
Volume 8
Issue 2 Supplement
Start page A12
End page A12
Total pages 1
Language eng
Formatted Abstract/Summary
There have been recent reports of epidemic strains of P.
aeruginosa in cystic fibrosis (CF) units, including two within Australia. Epidemic
strains do not seem to occur in all CF care settings despite the use of similar
molecular methods. The need for routine microbiological surveillance within CF
units therefore remains contentious.


Sputum was collected prospectively from all productive patients
attending the CF clinics at TPCH and RCH. All P. aeruginosa isolates were typed
using pulse field gel electrophoresis (PFGE) after digestion with SpeI, and
Tenover criteria applied to describe relatedness. Lung function, anthropometrics,
hospitalisations, demographics and antibiotic sensitivity data were recorded.


The first 100 patients (50 from each clinic) harboured 167 isolates.
Thirty-nine patients (62 isolates) shared an epidemic strain (pulsotype A), 20
patients shared a strain with at least one other patient and 41 patients harboured
unique strains (67 isolates). Eight patients shared a pulsotype identical to the
epidemic strain previously reported in Australia. Antibiograms showed pulsotype
A to be no more resistant than unique strains (multiresistance 27.4% vs. 16.4%,
c2 = 0.97, p > 0.2). Compared to those with unique strains, the pulsotype A group
were younger (mean age (SD) 16.7(7.3) versus 24 (12.3), p = 0.002) and had
similar lung function and hospitalisations.


Epidemic strains of P. aeruginosa are shared by a large proportion
of patients across two CF clinics in Brisbane. Our dominant pulsotype was neither
multiresistant nor associated with clinical parameters of more severe disease.
These findings support the need for routine microbiological surveillance within CF
Supported by the RCH Foundation
Subjects CX
730110 Respiratory system and diseases (incl. asthma)
321027 Respiratory Diseases
Keyword cystic fibrosis
epidemic strain
P. aeruginosa
Q-Index Code CX
Additional Notes Saturday 5 April – Respiratory Nurses SIG Oral Presentations (1030–1200)

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Created: Wed, 15 Aug 2007, 01:41:16 EST