In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy

Hickman, I. J., Powell, E. E., Prins, J. B., Clouston, A. D., Ash, S., Purdie, D. M. and Jonsson, J. R. (2003) In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy. Journal of Hepatology, 39 6: 1042-1048. doi:10.1016/S0168-8278(03)00463-X


Author Hickman, I. J.
Powell, E. E.
Prins, J. B.
Clouston, A. D.
Ash, S.
Purdie, D. M.
Jonsson, J. R.
Title In overweight patients with chronic hepatitis C, circulating insulin is associated with hepatic fibrosis: implications for therapy
Journal name Journal of Hepatology   Check publisher's open access policy
ISSN 0168-8278
Publication date 2003-12
Sub-type Article (original research)
DOI 10.1016/S0168-8278(03)00463-X
Volume 39
Issue 6
Start page 1042
End page 1048
Total pages 7
Editor Juan Rodes
Place of publication Amsterdam
Publisher Elsevier BV
Collection year 2003
Language eng
Subject C1
321004 Endocrinology
730105 Endocrine organs and diseases (incl. diabetes)
Abstract Background/Aims: Host factors such as increased body mass index (BMI) and genotype-specific viral factors contribute to the development of steatosis in patients with chronic hepatitis C (HCV). We hypothesized that host metabolic factors associated with increased BMI may play a role in disease progression. Methods: Fasting serum was collected from 160 patients with chronic HCV at the time of liver biopsy and 45 age, gender and BMI matched controls, and assessed for levels of insulin, c-peptide and leptin. Results: Patients with viral genotype 3 had more severe steatosis (P = 0.0001) and developed stages 1 and 2 fibrosis at a younger age (P < 0.05) than patients with genotype 1. For both genotypes, overweight patients had significantly more steatosis and increased insulin and leptin levels. In contrast to lean patients, there was a statistically significant increase in circulating insulin levels with increasing fibrosis in overweight patients with chronic HCV (P = 0.03). Following multivariate analysis, insulin was independently associated with fibrosis (P = 0.046) but not inflammation (P = 0.83). There was no association between serum leptin levels and stage of fibrosis. Conclusions: Increasing circulating insulin levels may be a factor responsible for the association between BMI and fibrosis in patients with HCV, irrespective of viral genotype. (C) 2003 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Keyword Gastroenterology & Hepatology
Hepatitis C (hcv)
Body Mass Index
Obesity
Insulin
Fibrosis
Steatosis
Inflammation
Leptin
Fatty Liver-disease
Homeostasis Model Assessment
Diabetes-mellitus
Virus-infection
Stellate Cells
Noncirrhotic Patients
Resistance
Glucose
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 01:37:11 EST