Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10

Martin, Ela, O'Sullivan, Brendan, Low, Pauline and Thomas, Ranjeny (2003) Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10. Immunity, 18 1: 155-167. doi:10.1016/S1074-7613(02)00503-4


Author Martin, Ela
O'Sullivan, Brendan
Low, Pauline
Thomas, Ranjeny
Title Antigen-specific suppression of a primed immune response by dendritic cells mediated by regulatory T cells secreting interleukin-10
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
Publication date 2003
Sub-type Article (original research)
DOI 10.1016/S1074-7613(02)00503-4
Volume 18
Issue 1
Start page 155
End page 167
Total pages 13
Editor Jennifer Scupi
Place of publication Cambridge, USA
Publisher Cell Press
Collection year 2003
Language eng
Subject C1
320202 Cellular Immunology
730102 Immune system and allergy
110322 Rheumatology and Arthritis
1107 Immunology
Abstract Antigen-specific suppression of a previously primed immune response is a major challenge for immunotherapy of autoimmune disease. ReIB activation is required for myeloid DC differentiation. Here, we show that antigen-exposed DCs in which ReIB function is inhibited lack cell surface CD40, prevent priming of immunity, and suppress previously primed immune responses. DCs generated from CD40-deficient mice similarly confer suppression. Regulatory CD4(+) T cells induced by the DCs transfer antigen-specific Infectious tolerance to primed recipients in an interleukin10-dependent fashion. Thus CD40, regulated by ReIB activity, determines the consequences of antigen presentation by myeloid DCs. These observations have significance for autoimmune immunotherapy and suggest a mechanism by which peripheral tolerance might be constitutively maintained by RelB(-) CD40(-) DCs.
Keyword Immunology
Kappa-b
In-vivo
Costimulatory Molecules
Nuclear Translocation
Cd40-deficient Mice
Targeted Disruption
Multifocal Defects
Toxoplasma-gondii
Relb
Expression
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 01:25:20 EST