Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells

Stewart, Trina J., Smyth, Mark J., Fernando, Germain J. P., Frazer, Ian H. and Leggatt, Graham R. (2003) Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells. Cancer Research, 63 12: 3058-3060.


Author Stewart, Trina J.
Smyth, Mark J.
Fernando, Germain J. P.
Frazer, Ian H.
Leggatt, Graham R.
Title Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells
Journal name Cancer Research   Check publisher's open access policy
ISSN 0008-5472
Publication date 2003-06
Sub-type Article (original research)
Volume 63
Issue 12
Start page 3058
End page 3060
Total pages 3
Editor Frank J. Rauscher III
Place of publication Birmingham, USA
Publisher American Association for Cancer Research
Collection year 2003
Language eng
Subject C1
320206 Tumor Immunology
730101 Infectious diseases
Abstract The role of natural killer T (NKT) cells in the immune response to tumor cells has been largely unexplored. As a model of adoptive tumor immunotherapy, cells from the draining lymph nodes of mice immunized with a tumor-specific or irrelevant antigen were transferred to naive recipients with established tumor. Inhibition of early tumor growth (day 4) required the transfer of both CD8(+) and Jalpha18(+) (NKT) cells from immunized animals without regard to immunogen. In contrast, CD8(+) cells, but not Jalpha18(+) cells, were necessary for the inhibition of late tumor growth (day 8). Thus, the developing tumor changes in sensitivity to NKT-mediated events and the role for NKT cells cannot be replaced by the presence of tumor-specific cells during early tumor growth. This suggests that recruitment/activation of Jalpha18(+) NKT cells is an important consideration during the immune therapy of early stage tumors.
Keyword Oncology
Nkt Cells
Immunosurveillance
Expression
Q-Index Code C1

 
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Created: Wed, 15 Aug 2007, 01:24:26 EST