Lipid rafts and caveolae as portals for endocytosis: New insights and common mechanisms

Parton, R. G. and Richards, A. A. (2003) Lipid rafts and caveolae as portals for endocytosis: New insights and common mechanisms. Traffic, 4 11: 724-738. doi:10.1034/j.1600-0854.2003.00128.x

Author Parton, R. G.
Richards, A. A.
Title Lipid rafts and caveolae as portals for endocytosis: New insights and common mechanisms
Journal name Traffic   Check publisher's open access policy
ISSN 1398-9219
Publication date 2003-11
Sub-type Article (original research)
DOI 10.1034/j.1600-0854.2003.00128.x
Volume 4
Issue 11
Start page 724
End page 738
Total pages 15
Editor Lisa Hannan
Place of publication Koebenhavn, Denmark
Publisher Blackwell Munksgaard
Collection year 2003
Language eng
Subject C1
270104 Membrane Biology
780106 Political science and public policy
Abstract Clathrin-coated pits and caveolae are two of the most recognizable features of the plasma membrane of mammalian cells. While our understanding of the machinery regulating and driving clathrin-coated pit-mediated endocytosis has progressed dramatically, including the elucidation of the structure of individual components and partial in vitro reconstitution, the role of caveolae as alternative endocytic carriers still remains elusive 50 years after their discovery. However, recent work has started to provide new insights into endocytosis by caveolae and into apparently related pathways involving lipid raft domains. These pathways, distinguished by their exquisite sensitivity to cholesterol-sequestering agents, can involve caveolae but also exist in cells devoid of caveolins and caveolae. This review examines the current evidence for the involvement of rafts and caveolae in endocytosis and the molecular players involved in their regulation.
Keyword Cell Biology
Cholera Toxin
Gpi-anchored Protein
Gpi-anchored Proteins
Clathrin-independent Internalization
Growth-factor Receptor
Class-i Molecules
Retrograde Transport
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2004 Higher Education Research Data Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 370 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 394 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 01:23:48 EST