Aging per se does not influence glucose homeostasis - In vivo and in vitro evidence

Imbeault, P, Prins, JB, Stolic, M, Russell, AW, O'Moore-Sullivan, T, Despres, JP, Bouchard, C and Tremblay, A (2003) Aging per se does not influence glucose homeostasis - In vivo and in vitro evidence. Diabetes Care, 26 2: 480-484. doi:10.2337/diacare.26.2.480

Author Imbeault, P
Prins, JB
Stolic, M
Russell, AW
O'Moore-Sullivan, T
Despres, JP
Bouchard, C
Tremblay, A
Title Aging per se does not influence glucose homeostasis - In vivo and in vitro evidence
Journal name Diabetes Care   Check publisher's open access policy
ISSN 0149-5992
Publication date 2003
Sub-type Article (original research)
DOI 10.2337/diacare.26.2.480
Volume 26
Issue 2
Start page 480
End page 484
Total pages 5
Editor Aime M Ballard
Mayer B Davidson
Place of publication USA
Publisher American Diabetes Association
Collection year 2003
Language eng
Subject C1
321004 Endocrinology
730105 Endocrine organs and diseases (incl. diabetes)
Abstract OBJECTIVE - To assess the effect of age on glucose metabolism by examining 1) glucose metabolism in young and middle-aged subjects when total or regional adiposity is taken into account and 2) in vitro glucose transport in adipose tissue explants from young and middle-aged women paired for total and abdominal adiposity. RESEARCH DESIGN AND METHODS - Study 1: body composition, subcutaneous abdominal and visceral adipose tissue areas, and fasting and oral glucose-stimulated glucose and insulin were measured in 84 young and 81 middle-aged men and in 110 young and 91 middle-aged women. Study 2: glucose uptake in subcutaneous abdominal and visceral adipose tissue explants were measured in eight young and eight middle-aged women. RESULTS - Study 1: young and middle-aged men showed similar subcutaneous abdominal tissue area, whereas fat mass and visceral adipose tissue were greater in middle-aged than in young men (P < 0.01). Fat mass and subcutaneous and visceral adipose tissue areas were greater in middle-aged as compared with young women (P < 0.01). Fasting plasma glucose and the glucose response to an oral glucose tolerance test were significantly higher in middle-aged than in young men and women (P < 0.001). Statistical control for visceral adipose tissue area eliminated the difference seen in glucose response in men and women. Study 2: glucose transport in subcutaneous and omental adipose tissue did not differ between young and middle-aged women. CONCLUSIONS - 1) Visceral obesity, more than age per se, correlates with glucose intolerance in middle-aged subjects; 2) aging does not influence in vitro adipose tissue glucose uptake.
Keyword Endocrinology & Metabolism
Visceral Adipose-tissue
Age-related Differences
Body-fat Distribution
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2004 Higher Education Research Data Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 36 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 01:23:23 EST