Abnormal left ventricular filling with increasing age reflects abnormal myocardial characteristics independent of ischemia or hypertrophy

Yuda, S, Short, L, Leano, R and Marwick, TH (2003) Abnormal left ventricular filling with increasing age reflects abnormal myocardial characteristics independent of ischemia or hypertrophy. American Journal of Cardiology, 91 1: 63-67.


Author Yuda, S
Short, L
Leano, R
Marwick, TH
Title Abnormal left ventricular filling with increasing age reflects abnormal myocardial characteristics independent of ischemia or hypertrophy
Journal name American Journal of Cardiology   Check publisher's open access policy
ISSN 0002-9149
Publication date 2003
Sub-type Article (original research)
DOI 10.1016/S0002-9149(02)02999-5
Volume 91
Issue 1
Start page 63
End page 67
Total pages 5
Editor Dr William C Roberts
Judy Wagner
Place of publication USA
Publisher Excerpta Medica, Inc
Collection year 2003
Language eng
Subject C1
730106 Cardiovascular system and diseases
321003 Cardiology (incl. Cardiovascular Diseases)
Abstract Abnormal left ventricular (IV) filling may occur with increasing age despite apparently normal IV size and function, and is usually attributed to IV hypertrophy and coronary artery disease. The purpose of this study was to determine whether myocardial abnormalities could be identified in 67 such patients (36 men, mean age 57 +/- 9 years) whose IV hypertrophy and coronary artery disease were excluded by dobutamine echocardiography. All patients underwent gray scale and color tissue Doppler imaging from 3 apical views, which were stored and analyzed off line. Disturbances in structure and function were assessed by averaging the cyclic variation of integrated backscatter, strain rate, and peak systolic strain from each myocardial segment. Calibrated integrated backscatter (corrected for pericardial backscatter intensity) was measured in the septum and posterior wall from the parasternal long-axis view. Abnormal IV filling was present in 36 subjects (54%). Subjects with and without abnormal IV filling had similar IV mass, but differed in age (p <0.01), cyclic variation (p = 0.001), strain rate (p <0.01), and peak systolic strain (p <0.001). Multivariate logistic regression analysis demonstrated that age (p = 0.016) and cyclic variation (p = 0.042) were the most important determinants of abnormal IV filling in these apparently normal subjects. (C) 2003 by Excerpta Medica, Inc.
Keyword Cardiac & Cardiovascular Systems
Ultrasonic Tissue Characterization
Diastolic Function
Integrated Backscatter
Doppler-echocardiography
Pressure-overload
Mitral Annulus
Human Hearts
Collagen
Hypertension
Dysfunction
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
2004 Higher Education Research Data Collection
School of Medicine Publications
 
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