Rates of gene rearrangement and nucleotide substitution are correlated in the mitochondrial genomes of insects

Shao, Renfu, Dowton, Mark, Murrell, Anna and Barker, Stephen C. (2003) Rates of gene rearrangement and nucleotide substitution are correlated in the mitochondrial genomes of insects. Molecular Biology and Evolution, 20 10: 1612-1619. doi:10.1093/molbev/msg176


Author Shao, Renfu
Dowton, Mark
Murrell, Anna
Barker, Stephen C.
Title Rates of gene rearrangement and nucleotide substitution are correlated in the mitochondrial genomes of insects
Journal name Molecular Biology and Evolution   Check publisher's open access policy
ISSN 0737-4038
Publication date 2003
Sub-type Article (original research)
DOI 10.1093/molbev/msg176
Volume 20
Issue 10
Start page 1612
End page 1619
Total pages 8
Editor Marcy Uyenoyama
Place of publication Lawrence, Kansas
Publisher Society for Molecular Biology and Evolution
Collection year 2003
Language eng
Subject C1
270208 Molecular Evolution
780105 Biological sciences
Abstract A number of studies indicated that lineages of animals with high rates of mitochondrial (mt) gene rearrangement might have high rates of mt nucleotide substitution. We chose the hemipteroid assemblage and the Insecta to test the idea that rates of mt gene rearrangement and mt nucleotide substitution are correlated. For this purpose, we sequenced the mt genome of a lepidopsocid from the Psocoptera, the only order of hemipteroid insects for which an entire mtDNA sequence is not available. The mt genome of this lepidopsocid is circular, 16,924 bp long, and contains 37 genes and a putative control region; seven tRNA genes and a protein-coding gene in this genome have changed positions relative to the ancestral arrangement of mt genes of insects. We then compared the relative rates of nucleotide substitution among species from each of the four orders of hemipteroid insects and among the 20 insects whose mt genomes have been sequenced entirely. All comparisons among the hernipteroid insects showed that species with higher rates of gene rearrangement also had significantly higher rates of nucleotide substitution statistically than did species with lower rates of gene rearrangement. In comparisons among the 20 insects, where the mt genomes of the two species differed by more than five breakpoints, the more rearranged species always had a significantly higher rate of nucleotide substitution than the less rearranged species. However, in comparisons where the mt genomes of two species differed by five or less breakpoints, the more rearranged species did not always have a significantly higher rate of nucleotide substitution than the less rearranged species. We tested the statistical significance of the correlation between the rates of mt gene rearrangement and mt nucleotide substitution with nine pairs of insects that were phylogenetically independent from one 2 another. We found that the correlation was positive and statistically significant (R-2 = 0.73, P = 0.01; R-s = 0.67, P < 0.05). We propose that increased rates of nucleotide substitution may lead to increased rates of gene rearrangement in the mt genomes of insects.
Keyword Biochemistry & Molecular Biology
Evolutionary Biology
Genetics & Heredity
Hemipteroid
Psocoptera
Mitochondrial Clock
Molecular Evolution
Rate Heterogeneity
Complete Dna-sequence
Relative-rate Test
Generation Time
Organization
Drosophila
Order
Arrangement
Sensitivity
Hymenoptera
Q-Index Code C1

 
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Created: Tue, 14 Aug 2007, 19:40:13 EST