Will chymase inhibitors be the next major development for the treatment of cardiovascular disorders?

Doggrell, Sheila A. and Wanstall, Janet C. (2003) Will chymase inhibitors be the next major development for the treatment of cardiovascular disorders?. Expert Opinion On Investigational Drugs, 12 8: 1429-1432.


Author Doggrell, Sheila A.
Wanstall, Janet C.
Title Will chymase inhibitors be the next major development for the treatment of cardiovascular disorders?
Journal name Expert Opinion On Investigational Drugs  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2003-08
Sub-type Article
DOI 10.1517/13543784.12.8.1429
Volume number 12
Issue number 8
ISSN 1744-7658
1354-3784
Start page 1429
End page 1432
Total pages 4
Editor J.D. Fitzgerald
Place of publication London, UK
Publisher Informa Healthcare
Collection year 2003
Language eng
Subject C1
320503 Clinical Pharmacology and Therapeutics
730106 Cardiovascular system and diseases
Abstract Chymase is contained in the secretory granules of mast cells. In addition to the synthesis of angiotensin II, chymase is involved in transforming growth factor-beta activation and cleaves Type I procollagen to produce collagen. NK301 and BCEAB are orally-active inhibitors of chymase. NK301 was tested in a dog model of vascular intimal hyperplasia after balloon injury and shown to reduce the increased chymase activity in the injured arteries and prevent intimal thickening. In a hamster model of cardiac fibrosis associated with cardiomyopathy, BCEAB reduced the increased cardiac chymase activity in cardiomyopathy and reduced fibrosis. Chymase inhibitors may be an important development for the treatment of cardiovascular injury associated with mast cell degranulation.
Keyword Pharmacology & Pharmacy
Bceab
Cardiomyopathy
Chymase Inhibition
Intimal Hyperplasia
Nk3201
Mast-cell Chymase
Restenosis
Tranilast
Trial
Q-Index Code C1

 
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Created: Tue, 14 Aug 2007, 19:39:35 EST