A molecular epidemiological study of Australian bat lyssavirus

Guyatt, Kimberley J., Twin, Jimmy, Davis, Patricia, Holmes, Edward C., Smith, Greg A., Smith, Ina L., Mackenzie, John S. and Young, Peter L. (2003) A molecular epidemiological study of Australian bat lyssavirus. Journal of General Virology, 84 2: 485-496.


Author Guyatt, Kimberley J.
Twin, Jimmy
Davis, Patricia
Holmes, Edward C.
Smith, Greg A.
Smith, Ina L.
Mackenzie, John S.
Young, Peter L.
Title A molecular epidemiological study of Australian bat lyssavirus
Journal name Journal of General Virology   Check publisher's open access policy
ISSN 0022-1317
1465-2099
Publication date 2003-02
Sub-type Article (original research)
DOI 10.1099/vir.0.18652-0
Volume 84
Issue 2
Start page 485
End page 496
Total pages 12
Place of publication Reading, UK
Publisher Society for General Microbiology
Collection year 2003
Language eng
Subject C1
270303 Virology
270208 Molecular Evolution
780105 Biological sciences
730212 Disease distribution and transmission
0605 Microbiology
0707 Veterinary Sciences
1108 Medical Microbiology
Formatted abstract The genetic diversity of Australian bat lyssavirus (ABL) was investigated by comparing 24 ABL isolate glycoprotein (G) gene nucleotide sequences with those of 37 lyssaviruses representing Lyssavirus genotypes 1-6. Phylogenetic analyses indicated that ABL forms a monophyletic group separate from other lyssaviruses. This group differentiates into two clades: one associated with Pteropus (flying fox) species, the other with the insectivorous bat Saccolaimus flaviventris. Calculation of percentage nucleotide identities between isolates of the two clades revealed up to 18.7 % nucleotide sequence divergence between the two ABL variants. These observations suggest that ABL is a separate lyssavirus species with a similar epidemiology to chiropteran rabies virus (RV), where two distinct ABL variants co-exist in Australia in bat species with dissimilar ecology. Analyses of selection pressures in ABL G gene sequences provided some evidence of weak positive selection within the endodomain at amino acids 499 and 501, although in general the dominant evolutionary process observed was purifying selection. This intimates that, in nature, isolates of ABL, like those of RV, are subject to relatively strong selective constraints, suggesting a stability of host species, cell tropisms and ecological conditions.
© 2003 SGM
Keyword Biotechnology & Applied Microbiology
Virology
Rabies virus glycoprotein
Long incubation period
United-states
Phylogenetic analysis
Nucleotide-sequences
Genome sequence
Receptor
Polymerase
Infection
Proteins
Q-Index Code C1
Additional Notes Published under "Animal: RNA Viruses". Article notes: "The GenBank accession numbers of the sequences reported in this paper are AF426290–AF426311."

 
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