5-Hydroxytryptamine and platelets: uptake and aggregation in hypoxic pulmonary hypertensive rats

Awabdy, Doreen, Bryan-Lluka, Lesley J. and Wanstall, Janet C. (2003) 5-Hydroxytryptamine and platelets: uptake and aggregation in hypoxic pulmonary hypertensive rats. European Journal of Pharmacology, 459 1: 1-7. doi:10.1016/S0014-2999(02)02734-6


Author Awabdy, Doreen
Bryan-Lluka, Lesley J.
Wanstall, Janet C.
Title 5-Hydroxytryptamine and platelets: uptake and aggregation in hypoxic pulmonary hypertensive rats
Journal name European Journal of Pharmacology   Check publisher's open access policy
ISSN 0014-2999
Publication date 2003-01-10
Sub-type Article (original research)
DOI 10.1016/S0014-2999(02)02734-6
Volume 459
Issue 1
Start page 1
End page 7
Total pages 7
Editor Gispen, W.
Nijkamp, F.
Versteeg, D.
Place of publication The Netherlands
Publisher Elsevier
Collection year 2003
Language eng
Subject C1
320502 Basic Pharmacology
730106 Cardiovascular system and diseases
Abstract Pulmonary hypertension is associated with various alterations in 5-hydroxytryptamine (5-HT) physiology. In this study in platelets from hypoxic pulmonary hypertensive rats (10% O-2; 1 week) and normoxic rats (room air), (i) initial rates of specific [H-3]5-HT uptake were measured and (ii) potentiation of collagen- and ADP-induced aggregation by 5-HT was quantified. The platelet count was almost halved in hypoxic rats. In uptake experiments, there was a decrease in 5-HT uptake in platelets from hypoxic compared with normoxic rats, due to a 36% reduction in the maximal initial rate of uptake. The aggregation experiments showed that 5-HT (1-100 muM) increased the magnitude of responses to collagen and the duration of responses to ADP, but there was no difference between hypoxic and normoxic rats. Abnormalities in platelet function may conceivably lead to increases in plasma 5-HT levels in hypoxic pulmonary hypertension, but are unlikely to aggravate pulmonary thromboembolism. (C) 2002 Elsevier Science B.V. All rights reserved.
Keyword Pharmacology & Pharmacy
Platelet
5-ht (5-hydroxytryptamine, Serotonin)
Sert (serotonin Transporter)
Hypoxic Pulmonary Hypertension
Aggregation
Smooth-muscle Cells
Serotonin Transporter
Artery
Fenfluramine
Receptors
Aminorex
Growth
Q-Index Code C1

 
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Created: Tue, 14 Aug 2007, 19:38:18 EST