The mouse secretome: functional classification of the proteins secreted into the extracellular environment

Grimmond, Sean M., Miranda, Kevin C., Yuan, Zheng, Davis, Melissa J., Hume, David A., Yagi, Ken, Tominaga, Naoko, Bono, Hidemasa, Hayashizaki, Yoshihide, Okazaki, Yasushi, RIKEN GER Group,, GSL Members, and Teasdale, Rohan D. (2003) The mouse secretome: functional classification of the proteins secreted into the extracellular environment. Genome Research, 13 6B: 1350-1359. doi:10.1101/gr.983703

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Author Grimmond, Sean M.
Miranda, Kevin C.
Yuan, Zheng
Davis, Melissa J.
Hume, David A.
Yagi, Ken
Tominaga, Naoko
Bono, Hidemasa
Hayashizaki, Yoshihide
Okazaki, Yasushi
RIKEN GER Group,
GSL Members,
Teasdale, Rohan D.
Title The mouse secretome: functional classification of the proteins secreted into the extracellular environment
Journal name Genome Research   Check publisher's open access policy
ISSN 1088-9051
1549-5469
Publication date 2003
Sub-type Article (original research)
DOI 10.1101/gr.983703
Open Access Status File (Publisher version)
Volume 13
Issue 6B
Start page 1350
End page 1359
Total pages 10
Place of publication Cold Spring Harbor, NY, United States
Publisher Cold spring Harbor Laboratory Press
Collection year 2003
Language eng
Abstract We have developed a computational strategy to identify the set of soluble proteins secreted into the extracellular environment of a cell. Within the protein sequences predominantly derived from the RIKEN representative transcript and protein set, we identified 2033 unique soluble proteins that are potentially secreted from the cell. These proteins contain a signal peptide required for entry into the secretory pathway and lack any transmembrane domains or intracellular localization signals. This class of proteins, which we have termed the mouse secretome, included >500 novel proteins and 92 proteins <100 amino acids in length. Functional analysis of the secretome included identification of human orthologs, functional units based on InterPro and SCOP Superfamily predictions, and expression of the proteins within the RIKEN READ microarray database. To highlight the utility of this information, we discuss the CUB domain-containing protein family.
Keyword Biotechnology & Applied Microbiology
Genetics & Heredity
Human Genome
Expression
Proteome
Sequence
Interpro
Database
Gene
Q-Index Code C1
Institutional Status UQ

 
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Created: Tue, 14 Aug 2007, 19:34:02 EST