Axon mis-targeting in the olfactory bulb during regeneration of olfactory neuroephithelium

St John, James A. and Key, Brian (2003) Axon mis-targeting in the olfactory bulb during regeneration of olfactory neuroephithelium. Chemical Senses, 28 9: 773-779. doi:10.1093/chemse/bjg068


Author St John, James A.
Key, Brian
Title Axon mis-targeting in the olfactory bulb during regeneration of olfactory neuroephithelium
Journal name Chemical Senses   Check publisher's open access policy
ISSN 0379-864X
1464-3553
Publication date 2003-11
Sub-type Article (original research)
DOI 10.1093/chemse/bjg068
Volume 28
Issue 9
Start page 773
End page 779
Total pages 7
Editor Wolfgang Meyerhof
Place of publication Oxford, U.K.
Publisher Oxford University Press
Collection year 2003
Language eng
Subject C1
270502 Neurobiology
780108 Behavioural and cognitive sciences
Formatted abstract During development, primary olfactory axons typically grow to their topographically correct target zone without extensive remodelling. Similarly, in adults, new axons arising from the normal turnover of sensory neurons essentially project to their target without error. In the present study we have examined axon targeting in the olfactory pathway following extensive chemical ablation of the olfactory neuroepithelium in the P2-tau:LacZ line of mice. These mice express LacZ in the P2 subpopulation of primary olfactory neurons whose axons target topographically fixed glomeruli on the medial and lateral surfaces of the olfactory bulb. Intraperitoneal injections of dichlobenil selectively destroyed the sensory neuroepithelium of the nasal cavity without direct physical insult to the olfactory neuron pathway. Primary olfactory neurons regenerated and LacZ staining revealed the trajectory of the P2 axons. Rather than project solely to their topographically appropriate glomeruli, the regenerating P2 axons now terminated in numerous inappropriate glomeruli which were widely dispersed over the olfactory bulb. While these errors in targeting were refined over time, there was still considerable mis-targeting after four months of regeneration.
© Oxford University Press 2003; all rights reserved.
Keyword Glomerulus
Guidance
Navigation
Neuron
Bromide-induced lesion
Topographic map
Organization
Q-Index Code C1
Additional Notes Author note, Dr James St John: "As primary author, I was responsible for the research output. This article was the first to demonstrate that, following widespread degeneration of the olfactory nerve, olfactory axons regrow into the brain, but go to incorrect targets. With time, these errors are corrected. These results support the known phenomenon in humans in which olfaction after injury can be perturbed but improves with time."

 
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